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Bangladesh Academy of Pathology


Bangladesh Academy of Pathology(BAP) aims to work with national and international organizations like International Academy of Pathology(IAP)to achieve excellence in education, training, research and quality service in Pathology in Bangladesh.

The Bangladesh Academy of Pathology was officially launched and its first general meeting was held in the Department of Pathology, Bangladesh Medical University, on Friday, the 7th of December 2012. A total of 58 specialist pathologists from all over the country were present at the meeting. Twenty Councillors were elected, amongst whom, the President, President elect, Vice President, Treasurer and General Secretary were selected for the next two years. The elected Councillors were: Dr. A J E Nahar Rahman (President), Dr. Mohammed Kamal (President elect), Dr. Kaniz Rasul (Vice President), Dr. Ashim Ranjan Barua (Treasurer), and Dr. Maleeha Hussain (General Secretary), Dr. Md Sadequel Islam Talukder, Dr. S M Badruddoza, Dr. Sukumar Saha, Dr. Abed Hossain, Dr. M Shahabuddin Ahmed, Dr. AFM Saleh, Dr. PK Gosh, Dr. Shabnam Akhter, Dr. Shamiul Islam Sadi, Dr. Kamrul Hassan Khan, Dr. Farooque Ahmed, Dr Abdul Mannan Sikder, Dr. Col. Mahbubul Alam, Dr. Taslima Hossain and Dr. AUM Muhsin.


 

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jhc2026v10i2s7


Original
Vimentin Expression in Renal Cell Carcinoma and It’s Association with Histological Grade and Pathological Stage
*Adhikary P,1 Begum S,2 Ferdous JN,3 Saha AK,4 Papry A,5 Emita U6

  1. *Dr. Priyanka Adhikary, MBBS, MD (Pathology), Junior consultant, Department of Pathology, Pirojpur District Hospital, Pirojpur, Bangladesh. priyanka003@gmail.com. ORCID: https://orcid.org/0009-0007-0148-2733.
  2. Dr. Shahnaj Begum, Professor & Head, Department of Pathology, Sir Salimullah Medical College, Dhaka, Bangladesh. Dr.shahnaj68@gmail.com ORCID: https://orcid.org/0009-0005-8210-1327.
  3. Dr. Jesmin Naz Ferdous, MBBS, MD(Pathology), Professor, Department of Pathology, Sir Salimullah Medical College, Dhaka, Bangladesh. Limaf888@gmail.com ORCID: https://orcid.org/0009-0009-5412-3958.
  4. Dr. Anjishu Kumar Saha, MSc (Statistics) Statistician, Khulna University, Khulna Bangladesh. anjishusaha9@gmail.com ORCID: https://orcid.org/0009-0004-2122-123X.
  5. Dr. Afsana Papry, MBBS, MD, Lecturer, Department of Pathology, Sir Salimullah Medical College, Dhaka, Bangladesh. Afsana.papry121.ap@gmail.com ORCID: https://orcid.org/0009-0003-6601-3955.
  6. Dr. Umama-Tun-Nesa Emita, MBBS, MD, Pathologist, Khulna Medical College and Hospital, Khulna, Bangladesh. Emita.rmc@gmail.com

*For correspondence
Abstract
Introduction: Renal cell carcinoma (RCC) is the most common type of kidney cancer and the incidence of it has been steadily increasing over the past few years. The precise prediction of prognosis is very important for planning an effective therapy and follow-up visits. There are some established prognostic factors, like- histological grade, pathological stage and tumor subtypes, but the tumor behavior is difficult to predict and may show different outcome. Immunohistochemical study of several molecular markers may be helpful in this regard.
Objectives: The aim of the present study was to evaluate the expression of vimentin in renal cell carcinoma and to determine it’s association with histological types, grades and pathological  stages.
Methods: This cross-sectional observational study was conducted with 35 cases of RCC for a period of 2 years in Department of Pathology, Sir Salimullah Medical College, Dhaka. In all of histopathologically diagnosed cases of renal cell carcinoma immunohistochemical staining was done. The collected data were organized and analyzed using Statistical Package for the Social Sciences (SPSS) version 25. Chi-square test, Fisher’s exact test and Spearman’s correlation test were used for statistical analysis. A p value of < 0.05 was considered as significant.
Results: The mean age of the study population was 53.17 ± 11.95 years & large number of patients (57.1%) were belonged to 41-60 years age group with male predominance (74.3%). Most of the patients (91.4%) presented with hematuria followed by 74.3% had flank pain and 51.4% had palpable renal mass. The most common subtype was clear cell carcinoma (68.6%) followed by papillary carcinoma (22.8%), chromophobe (5.7%) and collecting duct carcinoma (2.9%). Stage pT1 (40.0%) was the most frequent diagnosis of RCC followed by stage pT2 (34.3%) & Stage pT3 (25.7%). Grade 2 RCC was the most frequent diagnosis (40.6%) followed by 28.1% grade 3, 18.8% grade 4 and 12.5% grade 1 RCC. Vimentin expression was negative in chromophobe RCC but other subtypes showed variable degree of cytoplasmic expression of vimentin. Vimentin IHC expression was significantly high (≥8) with increase in the pathological T stage & WHO/ISUP grade of RCC (p-value 0.038 and 0.03 respectively).
Conclusion: Immunohistochemical expression of vimentin showed statistically significant association with the pathological T stage (pT) and histological grades (G) of renal cell carcinoma. Routine use of vimentin expression in conjunction with histopathological grading and staging may provide prognostic information to predict disease progression.
[Journal of Histopathology and Cytopathology, 2026 Jul; 10 (2):125-135]
DOI: https://www.doi.org/10.69950/jhc.2026.10.2.7

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jhc2026v10i2s6


Original
Histomorphological Pattern of Sellar and Suprasellar Region Tumor in Tertiary Level Hospital of Bangladesh
*Shirin S,1 Jeba R,2 Wahid SR,3 Nupur FP,4 Jannat MR5

  1. *Dr. Sadia Shirin, MD (Pathology), Lecturer, Department of Pathology, Dhaka Medical College, Dhaka, sadiashirin77@gmail.com. ORCID:https://orcid.org/0009-0006-6879-4208
  2. Dr. Ruksana Jeba, MD (Pathology), Professor and Head, Department of Pathology, Dhaka Medical College, Dhaka.ORCID: https://orcid.org/0009-0003-3025-7309
  3. Dr. Sadia Refat Wahid, MD (Pathology), Assistant Professor, Department of Pathology, Dhaka Medical College, Dhaka.ORCID: https://orcid.org/0009-0004-3821-7747
  4. Dr. Farjana Pervin Nupur, MD (Pathology), Assistant Professor, Department of Pathology, Dhaka Medical College, Dhaka, ORCID: https://orcid.org/0009-0009-5416-1073
  5. Dr. Mst Rubeyatul Jannat, MD (Pathology), Lecturer, Department of Pathology and Pharmacology, School of Medicine, IMU University, Kuala Lumpur, Malaysia. ORCID: https://orcid.org/0009-0007-8252-4375

*For correspondence

Abstract
Background: Sellar and suprasellar region tumors comprise a wide spectrum of neoplastic and non-neoplastic lesions with overlapping clinical and radiological features. Histopathological evaluation remains the gold standard for accurate diagnosis. The aim of this study was to observe the histomorphological pattern of sellar and suprasellar region tumors in a tertiary level hospital of Bangladesh.
Methods: This cross-sectional observational study was conducted in the Department of Pathology, Dhaka Medical College, from April 2023 to March 2024. A total of 125 radiologically diagnosed sellar and suprasellar lesions were included by purposive sampling. Tissue specimens obtained by biopsy were processed routinely and stained with hematoxylin and eosin for histopathological examination. Data were analyzed using SPSS version 24.0.
Results: Pituitary adenoma was the most common tumor, accounting for 72.8% of cases, followed by craniopharyngioma (12%) and meningioma (6.4%). The mean age of patients was 34±17.2 years, with slight male predominance (53.6%). Most tumors occurred in the 31–40 years age group. Headache was the most common presenting symptom (48.8%), and most tumors measured >4 cm radiologically. Adamantinomatous craniopharyngioma was the predominant subtype, mainly affecting children.
Conclusion: Pituitary adenoma was the predominant sellar and suprasellar tumor in this study. Histopathological examination remains essential for accurate diagnosis and differentiation of these lesions for appropriate management.
[Journal of Histopathology and Cytopathology, 2026 Jul; 10 (2):118-124]
DOI: https://www.doi.org/10.69950/jhc.2026.10.2.6
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jhc2026v10i2s5


Original
Immunohistochemical Expression of Extracellular Matrix Metalloproteinase Inducer (EMMPRIN/CD147) in Renal Cell Carcinoma and Its Association with Histological Grade and Pathological Stage
*Mahmud S,¹ Bhuiyan AZ,2  Hossain SA,3 Yasmin R,4  Saha MK,5 Masud MR,6 Shakila J,7  Afrin S8

  1. *Dr. SMA Mahmud, MD (Pathology), Assistant Professor, Department of Pathology, National Institute of Laboratory Medicine and Referral Center, Dhaka. mahmudmoon@gmail.com. ORCID:https://orcid.org/ 0009-0001-8975-2406
  2. Dr. ARM Zakaria Bhuiyan, MD (Pathology), Lecturer, Department of Pathology, Mymensingh Medical College, Mymensingh. ORCID:https://orcid.org/0009-0007-9374-6854.
  3. Dr. Shaikh Alamgir Hossain, MD (Pathology), Professor, Ex-Head Department of Pathology, Mymensingh Medical College, Mymensingh.
  4. Dr. Rubina Yasmin, MD (Pathology), Associate Professor, Department of Pathology, Mymensingh Medical College, Mymensingh. ORCID:https://orcid.org/0009-0005-4011-7056.
  5. Dr. Mridul Kumar Saha, MD (Pathology), Assistant Professor, Department of Pathology, Manikganj Medical College, Manikganj. ORCID:https://orcid.org/0009-0007-2079-7757.
  6. Dr. Md. Rakibul Islam Masud, FCPS (Radiotherapy), Radiotherapist, Department of Radiotherapy, MMCH, Mymensingh. ORCID:https://orcid.org/0009-0005-9509-1375.
  7. Dr. Jobaida Shakila, MBBS, Ex Assistant Registrar, Department of Gynaecology and Obstetrics, Delta Hospital Limited, Dhaka. ORCID:https://orcid.org/0009-0008-0778-
  8. Dr. Sadia Afrin, MBBS, Army Medical College, Jashore . ORCID:https://orcid.org/0009-0002-5326-3413. 

*For correspondence
Abstract
Background: Renal cell carcinoma (RCC) is the commonest malignant epithelial tumor of kidney. Histological grade and stage are major prognostic indicators; however, additional biomarkers may improve prognostic assessment. EMMPRIN/CD14 is associated with tumor invasion, angiogenesis, and metastasis. The aim of this study is to evaluate immunohistochemical expression of EMMPRIN/CD147 in RCC and determine its association with histological grade and pathological stage.
Methods: This cross-sectional study included 40 nephrectomy specimens diagnosed as RCC. Histological grading was done according to WHO/ISUP system and staging by AJCC TNM classification. Immunohistochemical staining for EMMPRIN/CD147 was performed and scored by intensity and proportion of stained cells.
Results: Clear cell RCC was the commonest subtype (67.5%). High EMMPRIN expression was observed in 27 (67.5%) cases. Strong membranous and cytoplasmic positivity was more frequent in higher grade and advanced stage tumors. Significant association was found between EMMPRIN expression and histological grade and pathological stage (p<0.05).
Conclusion: EMMPRIN/CD147 high expression is associated with aggressive behavior of RCC and may be a useful prognostic biomarker.
[Journal of Histopathology and Cytopathology, 2026 Jul; 10 (2):111-117]
DOI: https://www.doi.org/10.69950/jhc.2026.10.2.5

 

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