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JHC 2023 v7 i2 s2

Original Contribution

Ultrasound Guided Fine Needle Aspiration Cytology of Lung
Lesions

1. *Dr. Rukhshana Akhter Jahan, Associate Professor, Department of Pathology, Rajshahi Medical College,
Rajshahi. jahanrukhshana@gmail.com
2. Professor Dr. S M Asafudullah, Professor & Head, Department of Pathology, Rajshahi Medical College,
Rajshahi. drshamol@gmail.com
3. Dr. Rebeka Sultana, Consultant Pathologist, Raj Pathology, Rajshahi. doctorrebekasultana@gmail.com
4. Dr. S. M. Moshaddeq Hossain, Assistant Professor, Department of Pathology, Rajshahi Medical College,
Rajshahi. mridulrmcbd@yahoo.com
5. Dr. Samrose Sultana, Assistant Professor, Department of Pathology, Pabna Medical College, Pabna.
samrosesina@gmail.com

Abstract
Background: This study was aimed to evaluate the role of transthoracic ultrasound guided
FNAC in diagnosis of peripheral lung lesion. It is an important and useful investigation to
differentiate between benign and malignant lesions of lung. USG guided FNAC of lung lesion
is a safe, radiation free, and cost effective method. Besides, the procedure is simple and
complications if occur, can be managed conservatively.
Methods: This was a cross-sectional study conducted at the department of Pathology,
Rajshahi Medical College. Some samples were also collected from a private diagnostic centre,
Rajshahi over a period of one year from January 2021 to December 2021. 150 patients who
fulfilled inclusion criteria were included in this study. After properly explaining the procedure
and taking informed consent, USG guided FNAC was done in all the patients. Radiological
and cytological data of enrolled patients was collected prospectively and analyzed.
Results: Among the 150 patients, this study comprising of 120 male and 30 female in age
range of 21 to 90 years. Malignancy was the most common cytological diagnosis (76%) while
as benign diagnosis was reached in 22.66%. In 1.33% of patients, FNAC was inconclusive.
Squamous cell carcinoma was the most common malignancy diagnosed in 46(30.66%)
patients, followed by adonocarcinoma 31(20.66%), 19(12.66%) patients had undifferentiated
carcinoma, metastatic carcinoma 09(06%), small cell carcinoma 07(4.66%), and Non Hodgkin
lymphoma was diagnosed in 02(1.33%) patients. Among the benign group, nonspecific
chronic inflammation was diagnosed in 18(18%) patients, tuberculous granuloma 07(4.66%),
while the smear was inconclusive in 02(1.33%) patients.
Conclusion: Ultrasound guided fine needle aspiration cytology is safe, less expensive, less
time consuming, less invasive diagnostic tool with high degree of accuracy and no radiation
toxicity to lung lesions

[Journal of Histopathology and Cytopathology, 2023 Jul; 7 (2):55-61]
Keywords: Malignancy, Tuberculosis, USG guided Fine needle aspiration cytology.

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JHC 2023 July v7 i2 s1

Editorial

Challenges and Prospects of Establishing a Genome Sequencing Laboratory in Bangladesh

Dr. DM Arifur Rahman
Associate Professor (Histopathology), TMSS Medical College, Bogura. arifurrahmandm@gmail.com
Abstract: Not available
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JHC 2023 July v7 i1 s2

Original Contribution

Immunohistochemical Evaluation of Ki67 Expression in Premalignant and Malignant Esophageal Lesions – Study of 54 Cases in a Tertiary Care Hospita

1. *Dr. Shifayat Sultana, Assistant Professor, Department of Pathology, Central Medical College, Cumilla.
shifayat.sultana.ss@gmail.com
2. Dr. Syeda Sadia Afrin, Lecturer, Department of Pathology, Dhaka Medical College, Dhaka.
3. Dr. Zubaida Bahroon Khan, Associate Professor, Department of Pathology, Dhaka Medical College, Dhaka.
4. Dr. Shirin Gull Zabin, Assistant Professor, Department of Pathology, Dhaka Medical College, Dhaka.
5. Dr. Rumana Afrin Sweety, Assistant Professor, Department of Pathology, Marks Medical College, Dhaka.
6. Dr. Md. Ariful Islam, Assistant Professor, Department of Pathology, Monowara Sikder Medical College,
Shariatpur.
7. Dr. Nazma Shaheen, Assistant Professor, Department of Pathology, Gonoshasthaya Samaj Vittik Medical College,
Dhaka.
8. Dr. Fatima Tuj Jahra, Assistant Professor, Department of Pathology, Aichi Medical College, Dhaka.
9. Professor Dr. Ruksana Jeba, Professor and Head, Department of Pathology, Dhaka Medical College, Dhaka.
10. Professor Dr. Rezaul Karim Dewan, Professor and Head, Department of Pathology, Greenlife Medical College,
Dhaka.
*For correspondence

Abstract
Background: In Bangladesh esophageal carcinoma is the leading malignant condition. Mortality
rate of esophageal cancer is very high. Like other malignancies, early detection offers the best
prognosis for esophageal carcinoma. Regular endoscopic and histologic surveillance have become
standard procedure for follow up of patients with premalignant lesions. But sometimes
histomorphological diagnosis on routine biopsies can be challenging for pathologist. Several
studies showed that positive Ki67 expression is significantly associated with higher grade of
esophageal lesions and is a potential prognostic marker.
Objectives: The aim of the present study was to evaluate Ki67 expression in each
histopathological category and to investigate the relationship of Ki67 with premalignant and
malignant esophageal lesions.
Methods: This study was a cross sectional study, carried out at the department of Pathology in
Dhaka Medical College and Hospital from March 2018 to February 2020. Total 54 cases of
esophageal biopsy were included in this study. They were divided in maligant and premalignant
category. All obtained samples were selected for routine histopathological study and
immunostaining for Ki67 was done in formalin fixed paraffin embedded tissue.
Results: Most of the patients were male and mean age was 55.04 (±15.48) years. Squamous cell
carcinoma was the most common malignancy seen in (26 cases) 48.15 % of patients and Barrett’s
esophagus was common (13 cases, 24.07%) premalignant lesion. Ki67 expression was found
statistically significant (p<0.05) when correlated with histomorphologic grading of premalignant
and malignant lesions. Calculation result of malignant and premalignant category as a whole
should be stated.
Conclusion: Ki67 expression positively correlates with histomorphologic grading of premalignant
and malignant esophageal lesions.

[Journal of Histopathology and Cytopathology, 2023 Jan; 7 (1):3-11]
Keywords: Barrett’s esophagus, esophageal carcinoma, Ki67

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