jhc.2026.10.1.8

Journal of Histopathology and Cytopathology

Official Journal of Bangladesh Academy of Pathology

Vol 10, No 1, January 2026

Histopathologic Findings of Breast Lesions and It’s Association with Corresponding Radiologic Findings.

*Datta T,¹ Asaduzzaman,² Ray TK,³ Hoque MM⁴

Abstract
Background: Invasive breast carcinoma is one of the most common carcinoma in women. Breast Imaging-Reporting and Data System (BI-RADS) classification besides histopathology has become an important tool for evaluation of malignant breast diseases. The purpose of this study is to assess the similarity between radiological and histopathological findings and illustrate the predictive value in the BI-RADS category.
Methods: This is a retrospective study, done at National Institute of Burn and Plastic Surgery, Dhaka from January 2023 to December 2023, included those patients who had radiological examination with BI-RADS categories 3, 4 and 5 followed by histopathological examination to confirm the diagnosis based on breast core biopsy and excision specimen within 1 year. The clinico-radiologic features were correlated with the histopathologic results using the chi- square test. The scoring system was designed based on the significant predictive features of malignancy, and its diagnostic performance was compared with that of the Breast Imaging-Reporting and Data System (BI-RADS) category.
Result: Among 111 cases, by histopathological diagnosis, malignancy was found in 54 cases (48.6%) and benign was found in 57 cases (51.4%). BI-RADS scoring category 3,4 and 5 cases were 51(45.9%), 26(23.4%) and 34(30.6%) respectively. P-value from Chi-square test shows strong association of malignancy with age ≥50, post-menopause and higher BI-RADS categories like 4 and 5. Overall, the breast lesions evaluated by BI-RADS classification have a sensitivity of 94.48%, specificity of 43.14%, a PPV of 63.9% and a NPV of 88%.
Conclusion: A strong association was found between BI-RADS score 4,5 and histopathologically diagnosed malignant lesion.

[Journal of Histopathology and Cytopathology, 2026 Jan; 10 (1):63-70]
DOI: https://www.doi.org/10.69950/jhc.2026.10.1.8

Keywords: Breast Lesion, BI-RADS, Histopathology, Association.

*Dr. Tanusree Datta, MBBS, MD (Pathology), Assistant Professor, Pathology Department, National Institute of Burn and Plastic Surgery, Dhaka. tanusreebsmmu89@gmail.com.
Dr. Asaduzzaman, MBBS, MD (Pathology), Associate Professor, Pathology Department, National Institute of Burn and Plastic Surgery, Dhaka.
Dr. Major Tapan Kumar Ray, MBBS, FCPS Trainee Officer, Combined Military Hospital, Dhaka.
Dr. Mohammad Mahabubul Hoque, MBBS, MD (Pathology), M. Med, Associate Professor, Pathology Department, National Institute of Laboratory Medicine and Referral Centre, Dhaka.

*For correspondence
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09/07/2024

JHC 2023 January v7 i1 s4

Original Contribution

Role of FNAC and Core Needle Biopsy in the Diagnosis of Breast Lesions

1.*Dr. Anindita Sarkar, MD (Pathology), Assistant Professor (C.C), Pathology Department, Rajshahi Medical
College. abantica.16@gmail.com.
2. Prof. Dr. S. M. Asafudullah, MD (Pathology), Professor and Head of Department of Pathology, Rajshahi Medical
College.
3. Dr. Khadiza Khanam, MD (Pathology), Professor, Pathology Department, Rajshahi Medical College.
4. Dr. Rukhshana Akhter Jahan, MD (Pathology), Associate Professor, Pathology Department, Rajshahi Medical
College.
5. Dr. Tanshina Afrin, MD (Pathology), Assistant Professor (C.C), Pathology Department, Rajshahi Medical College.
6. Dr. Rebeka Sultana, MD (Pathology), Consultant, Islami Bank Hospital, Rajshahi.
*For correspondence

Abstract
Background: Though excision biopsy of breast lump is considered to be the gold standard method
for diagnosis, there should be an improved and definitive method for establishing an accurate
diagnosis of breast lesions prior to surgery. This study was carried out to evaluate the efficacy and
diagnostic performance of fine needle aspiration cytology (FNAC) and core needle biopsy (CNB)
in the preoperative assessment of breast lesions.
Methods: This cross-sectional study was conducted in the private diagnostic center in Rajshahi,
Bangladesh over a period of one year from January 2022 to December 2022.A total of 60 cases
were subjected to both FNAC and CNB from the same breast lesions included in this study.
Result: The age range of total 60 patients was 22-85 years with mean age of 42.18 ±SD 12.15
years. 38 patients had benign lesions and 22 had malignant tumors. Sensitivity, specificity, positive
predictive value, negative predictive value, and diagnostic accuracy for FNAC were 89.4%, 100%,
100%, 84.6%, and 93.3%, respectively in diagnosing carcinoma. CNB had sensitivity, specificity,
positive predictive value, negative predictive value, and diagnostic accuracy of 94.7%, 100%,
100%, 91.6% and 91.6% respectively. Both FNAC and CNB showed statistically significant
association.
Conclusion: Taking into account the benefits and outcomes, combined approach of FNAC and
CNB can provide accurate preoperative diagnosis of breast lesions and provide important
information for appropriate treatment

[Journal of Histopathology and Cytopathology, 2023 Jan; 7 (1):21-26]
Keywords: FNAC, Core needle biopsy (CNB), Breast lesion

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08/07/2024

JHC 2023 July v7 i2 s3

Original Contribution

Histomorphological Patterns of Different Breast Lesions in a Tertiary Care Hospital

1. *Dr. Tanshina Afrin, MD (Pathology), Assistant Professor (C.C), Pathology Department, Rajshahi Medical
College. tanshinaafrin@gmail.com
2. Prof. Dr. S M Asafudullah, Professor and Head of Department of Pathology, Rajshahi Medical College
3. Dr. Khadiza Khanam, Professor, Pathology Department, Rajshahi Medical College.
4. Dr. Arefa Sultana, Associate Professor, Pathology Department, Rajshahi Medical College.
5. Dr. Anindita Sarkar, Assistant Professor (C.C), Pathology Department, Rajshahi Medical College.
6. Dr. Nazifa Islam, Assistant Professor (C.C), Pathology Department, Rajshahi Medical College.
7. Dr. Samrose Sultana, Assistant Professor (C.C) Pathology Department, Rajshahi Medical College.
* For correspondence

Abstract
Objective: Breast lesions are heterogeneous diseases that consist of several distinct entities
with remarkably different characteristic features. The present study was conducted to assess
histopathological findings of breast lesions in excision biopsy samples.
Methods: This cross-sectional study was conducted in the Department of Pathology, Rajshahi
Medical College over a period of one year from July 2021 to June 2022. A total of 105 cases of
breast lesions were included in this study.
Result: Out of 105 cases of breast lesions studied, 59 cases (72%) were malignant and 46 cases
were benign lesions. Fibroadenoma (18 cases out of 46) was the most common benign lesion
followed by breast abscess (9 cases out of 46). On the other hand, invasive ductal carcinoma
was the highest occurred malignant tumour (59 cases, 56%). The age range of breast lesion was
15 to 75 yrs and highest incidence was in between 31-50 years (both benign and malignant).
Most of the breast lesions were occurred in left breast (62%).
Conclusion: Histopathological examination plays an important role in differentiating between
benign and malignant lesions. In the present study the most common benign breast lesion was
fibroadenoma and the most common malignant lesion was infiltrating ductal carcinoma. The

[Journal of Histopathology and Cytopathology, 2023 Jul; 7 (2):62-68]
Keywords: Histopathology, Malignant, Benign lesions, Breast lesion

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