Tag: Colorectal Adenocarcinoma

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jhc2025v9i2s5

Journal of Histopathology and Cytopathology

Official Organ of Bangladesh Academy of Pathology

Vol 9, No 2, July 2025

Role of WT1 Immunoexpression in Colorectal Adenocarcinoma: A Study in a Tertiary Care Hospital

*Nupur FP,1 Jeba R,2 Khan ZB,3 Karim SS,4 Zabin SG,5 Khan RR,6 Dewan RK,7 Jinnah MS8

  1. *Dr. Farjana Pervin Nupur, MBBS, MD (Pathology), Pathologist, Dhaka Medical College, Dhaka, pervin_farjana@yahoo.com
  2. Ruksana Jeba, MBBS, MD (Pathology), Professor and head, Department of pathology, Dhaka Medical College, Dhaka,ruksanajeba67@gmail.com
  3. Zubaida Bahroon Khan, MBBS, MD (Pathology), Associate professor, Department of pathology, Dhaka Medical College, Dhaka, zubaida@gmail.com
  4. Saiyeda Sinthia Karim, MBBS, MD (Pathology), Associate professor, National Institute of Laboratory Medicine and Referral centre, Dhaka, sinthiakarim330@gmail.com
  5. Shirin Gull Zabin, MBBS, MD (Pathology), Assistant professor, Department of pathology, Dhaka Medical College, Dhaka, gullzabin23@gmail.com
  6. Rizwana Rahman Khan, MBBS, MD (Pathology), Assistant professor, Department of pathology, Dhaka Medical College, Dhaka, drizwanasbmc@gmail.com
  7. MD. Rezaul Karim Dewan, MBBS, MD (Pathology), Professor and head, Department of Pathology, Greenlife Medical College Hospital, Dhaka, rezadewan22@gmail.com
  8. Mohammed Shahed Ali Jinnah, MBBS, MD (Pathology), Professor and ex-director, National Institute of Laboratory Medicine & Referral Centre, Dhaka, shahed.jinnah63@gmail.com

* For correspondence
Abstract
Background: Wilms Tumor 1 (WT1) is a transcription factor involved in cellular proliferation and differentiation, with emerging relevance in various malignancies including colorectal adenocarcinoma (CRC). The aim of this study was to assess the immunohistochemical expression of WT1 in colorectal adenocarcinoma and determine its association with age, gender, histological type, grade, stage, lymphovascular invasion (LVI), and perineural invasion (PNI).
Methods:This cross-sectional observational study included 97 histopathologically diagnosed cases of colorectal adenocarcinoma, selected using purposive sampling. The study was conducted at the Department of Pathology, Dhaka Medical College Hospital, while WT1 mmunohistochemistry was performed at the Immunohistochemistry Laboratory of Bangladesh Medical University, Dhaka. The study duration was from March 2021 to February 2025. Qualitative data were expressed as frequency and percentage. The Chi- square and Fisher’s exact test were used to assess the relation    between qualitative variables. A p-value less than 0.05 were considered as significant.
Results:Among 97 cases, 55% showed low and 45% showed high WT1 expression. High WT1 expression was significantly associated with mucinous type (p=0.0214), poorly differentiated tumors (p=0.0012), and advanced pathological T (p=0.0007) and N stages (p=0.0003). No significant association was observed with age, gender, LVI, or PNI.
Conclusion: WT1 immunoexpression associates with aggressive histopathological features in colorectal adenocarcinoma, suggesting its potential role as a prognostic marker.

[Journal of Histopathology and Cytopathology, 2025 Jul; 9 (2):97-104]
DOI: https://www.doi.org/10.69950/jhc2025v9i2s5

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