Case Report
Heterotopic Ossification of the Gallbladder Associated with Chronic Cholecystitis: A Case Report
*Anjum R,¹ Hossain  GZ²

1. *Dr. Rahat Anjum, Associate Consultant, Histopathology & Cytopathology, Apollo Imperial Hospitals, Zakir Hossain Road, Chittagong r.dr@gmail.com. ORCID: https://orcid.org/0009-0005-2233-6992
2. Dr. GM Zakir Hossain, Professor, Department of Urology, Chittagong Medical College Hospital. ORCID: https://orcid.org/ 0009-0004-5050-6058

*For correspondence
Abstract
Hetrotopic ossification  in the gall bladder is a rare condition, with  few reported cases. Its pathogenesis remains unclear, though chronic  inflammation may predispose to the condition. An  18 yr old girl underwent laparoscopic cholecystectomy due to persistent upper quadrant pain, nausea and postprandial vomiting. Preoperative ultrasound revealed a polyp with features  of  cholecystitis. The post operative course was uneventful.  Histopathological examination showed fibromuscular hyperplasia, infiltration of chronic inflammatory cells, including foamy histiocytes in the lamina propria. Rokitansky–Aschoff sinuses were present. The polypoid area exhibited denuded epithelium, mature bone formation and marrow elements without evidence of metaplasia,  dysplasia or malignancy.
[Journal of Histopathology and Cytopathology, 2026 Jul; 10 (2):160-162]
DOI: https://www.doi.org/10.69950/jhc.2026.10.2.11
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Journal of Histopathology and Cytopathology

Official Organ of Bangladesh Academy of Pathology

Vol 9, No 2, July 2025

Heterotopic Ossification of the Gallbladder Associated with Chronic Cholecystitis: A case Report

*Anjum R,¹ Hossain GZ ²

1. *Dr. Rahat Anjum, Associate Consultant, Histopathology & Cytopathology, Apollo Imperial Hospitals, Zakir Hossain Road, Chittagong. r.dr@gmail.com
2. G.M Zakir Hossain, Professor, Department of Urology, Chittagong Medical College Hospital

*For correspondence
Abstract
Heterotopic ossification in the gall bladder is a rare condition, with few reported cases. Its pathogenesis remains unclear, though chronic inflammation may predispose to the condition. An 18-year-old girl underwent laparoscopic cholecystectomy due to persistent upper quadrant pain, nausea, and postprandial vomiting. Preoperative ultrasound revealed a polyp with features of cholecystitis. The post-operative course was uneventful.  Histopathological examination showed fibromuscular hyperplasia, infiltration of chronic inflammatory cells, including foamy histiocytes, in the lamina propria. Rokitansky–Aschoff sinuses were present. The polypoid area exhibited denuded epithelium, mature bone formation, and marrow elements without evidence of metaplasia,  dysplasia or malignancy.

[Journal of Histopathology and Cytopathology, 2025 Jul; 9 (2):111-113]
DOI: https://www.doi.org/10.69950/jhc2025v9i2s7

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