Tag: Ki67

Posted on

JHC 2023 v7 i2 s9

Case Report

STUMP of Prostate Gland – Case Report

1.*Dr. Afroza Begum, Associate Professor, Department of Pathology, Anwer Khan Modern Medical College.
afroza.mithila@gmail.com
2. Dr. Azfar Uddin Shaikh, Assistant Professor, Urology, Anwer Khan Modern Medical College
3. Prof. Mohammed Kamal, Chief Consultant, The Laboratory, Ex-Chairman and Head of the Department of
Pathology, BSMMU
*For correspondence
Abstract
Specialized stromal tumours of prostate includes stromal tumors of uncertain malignant potential
(STUMP) and stromal sarcoma. Florid Benign prostatic hyperplasia must be differentiated from
prostatic stromal neoplasia. Prostatic STUMPs may have significant overlap with florid stromal
hyperplasia. A case of prostatic STUMP is reported in this article. A 56 years old man presented
with dysuria. Ultrasonography and CT scan showed inhomogenous parenchyma and highly
suspicious lesion in posterior transition zone and postero-lateral peripheral zone of left lobe at mid
gland of prostate. Capsular invasion was absent. Core biopsy revealed nodular hyperplasia with
focal phyllodes like atypical stromal hyperplasia (STUMP). PSA level was 7.2 ng/ml. We should
observe the glandular epithelial neoplasia and stromal cells changes during histopathological
diagnosis because sarcomatouus changes in stromal cells is equally devastating as carcinoma

[Journal of Histopathology and Cytopathology, 2023 Jul; 7 (2):112-115]
Keywords: Stromal tumour of uncertain malignant potential (STUMP), Prostate specific antigen
(PSA), Ki67 (Proliferative index), PI-RADS, BPH (Benign prostatic hyperplasia)

Full article in

PDF

Posted on

JHC 2023 July v7 i1 s2

Original Contribution

Immunohistochemical Evaluation of Ki67 Expression in Premalignant and Malignant Esophageal Lesions – Study of 54 Cases in a Tertiary Care Hospita

1. *Dr. Shifayat Sultana, Assistant Professor, Department of Pathology, Central Medical College, Cumilla.
shifayat.sultana.ss@gmail.com
2. Dr. Syeda Sadia Afrin, Lecturer, Department of Pathology, Dhaka Medical College, Dhaka.
3. Dr. Zubaida Bahroon Khan, Associate Professor, Department of Pathology, Dhaka Medical College, Dhaka.
4. Dr. Shirin Gull Zabin, Assistant Professor, Department of Pathology, Dhaka Medical College, Dhaka.
5. Dr. Rumana Afrin Sweety, Assistant Professor, Department of Pathology, Marks Medical College, Dhaka.
6. Dr. Md. Ariful Islam, Assistant Professor, Department of Pathology, Monowara Sikder Medical College,
Shariatpur.
7. Dr. Nazma Shaheen, Assistant Professor, Department of Pathology, Gonoshasthaya Samaj Vittik Medical College,
Dhaka.
8. Dr. Fatima Tuj Jahra, Assistant Professor, Department of Pathology, Aichi Medical College, Dhaka.
9. Professor Dr. Ruksana Jeba, Professor and Head, Department of Pathology, Dhaka Medical College, Dhaka.
10. Professor Dr. Rezaul Karim Dewan, Professor and Head, Department of Pathology, Greenlife Medical College,
Dhaka.
*For correspondence

Abstract
Background: In Bangladesh esophageal carcinoma is the leading malignant condition. Mortality
rate of esophageal cancer is very high. Like other malignancies, early detection offers the best
prognosis for esophageal carcinoma. Regular endoscopic and histologic surveillance have become
standard procedure for follow up of patients with premalignant lesions. But sometimes
histomorphological diagnosis on routine biopsies can be challenging for pathologist. Several
studies showed that positive Ki67 expression is significantly associated with higher grade of
esophageal lesions and is a potential prognostic marker.
Objectives: The aim of the present study was to evaluate Ki67 expression in each
histopathological category and to investigate the relationship of Ki67 with premalignant and
malignant esophageal lesions.
Methods: This study was a cross sectional study, carried out at the department of Pathology in
Dhaka Medical College and Hospital from March 2018 to February 2020. Total 54 cases of
esophageal biopsy were included in this study. They were divided in maligant and premalignant
category. All obtained samples were selected for routine histopathological study and
immunostaining for Ki67 was done in formalin fixed paraffin embedded tissue.
Results: Most of the patients were male and mean age was 55.04 (±15.48) years. Squamous cell
carcinoma was the most common malignancy seen in (26 cases) 48.15 % of patients and Barrett’s
esophagus was common (13 cases, 24.07%) premalignant lesion. Ki67 expression was found
statistically significant (p<0.05) when correlated with histomorphologic grading of premalignant
and malignant lesions. Calculation result of malignant and premalignant category as a whole
should be stated.
Conclusion: Ki67 expression positively correlates with histomorphologic grading of premalignant
and malignant esophageal lesions.

[Journal of Histopathology and Cytopathology, 2023 Jan; 7 (1):3-11]
Keywords: Barrett’s esophagus, esophageal carcinoma, Ki67

Full Text

PDF