Tag: Malignant

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jhc2025v9i1s3

Original Article

Expression of Estrogen Receptor and Progesterone Receptor in Malignant Epithelial Ovarian Tumors

*Shams S,1 Das R,2 Saha S3

  1. * Sifat Shams, Medical Officer, Department of Neuropathology, National Institute of Neurosciences and Hospital, Dhaka, Bangladesh. sifatshams24@gmail.com.
  2. Reba Das, Assistant Professor, Department of Pathology, Sathkhira Medical College Hospital, Sathkhira, Bangladesh
  3. Shawni Saha, Assistant Professor, Department of Pathology, Shaheed Suhrawardy Medical College Hospital, Bangladesh

*For correspondence

Abstract

Background: Malignant epithelial ovarian tumors are a significant cause of cancer-related deaths in women. The expression of estrogen and progesterone receptors (ER and PR) in these tumors has been studied extensively, as they play a critical role in the pathogenesis and treatment of ovarian cancer. ER and PR expression levels in ovarian tumors can impact treatment decisions and patient outcomes. Therefore, understanding the frequency and distribution of ER and PR expression in different types of ovarian tumors is crucial in improving patient care.

Method: This cross-sectional observational study was conducted at the Department of Pathology, Sir Salimullah Medical College and Mitford Hospital, Dhaka, Bangladesh. The study duration was 2 years, from January 2018 to December 2019. During this period, a total of 45 adult female patients with histopathologically diagnosed malignant epithelial ovarian tumors by H&E staging were selected for the study.

Results: In this study, the majority of participants were aged 41-60 years and reported irregular menstrual cycles or being post-menopausal. Most were nulliparous, and the mean CA125 level was 149.51. Serous cystadenocarcinoma was the most common diagnosis (68.89%). ER was positive in 51.11% of cases, with a higher proportion in serous cystadenocarcinoma (64.52%) compared to mucinous cystadenocarcinoma. PR was positive in 80% of cases, with the highest proportion in endometrioid carcinoma (50%). ER expression was significantly higher in serous tumors compared to non-serous tumors (p=0.002), but the association between tumor type and PR expression was not significant (p=0.192).

Conclusion: The study found that the majority of participants were aged 41-60 years, had irregular menstrual cycles, or were post-menopausal. Serous cystadenocarcinoma was the most common diagnosis. A significant difference in ER positivity was observed between serous and mucinous cystadenocarcinoma, as well as other subtypes. PR positivity was observed in the majority of participants, but no significant association was observed with histopathological subtypes or serous types.

[Journal of Histopathology and Cytopathology, 2025 Jan; 9 (1):10-19]

DOI: https://www.doi.org/10.69950/jhc2025v9i1s3

 Keywords:  Estrogen, Progesterone, Cancer, Carcinoma, Ovarian, Malignant

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JHC 2023 July v7 i2 s3

Original Contribution

Histomorphological Patterns of Different Breast Lesions in a Tertiary Care Hospital

1. *Dr. Tanshina Afrin, MD (Pathology), Assistant Professor (C.C), Pathology Department, Rajshahi Medical
College. tanshinaafrin@gmail.com
2. Prof. Dr. S M Asafudullah, Professor and Head of Department of Pathology, Rajshahi Medical College
3. Dr. Khadiza Khanam, Professor, Pathology Department, Rajshahi Medical College.
4. Dr. Arefa Sultana, Associate Professor, Pathology Department, Rajshahi Medical College.
5. Dr. Anindita Sarkar, Assistant Professor (C.C), Pathology Department, Rajshahi Medical College.
6. Dr. Nazifa Islam, Assistant Professor (C.C), Pathology Department, Rajshahi Medical College.
7. Dr. Samrose Sultana, Assistant Professor (C.C) Pathology Department, Rajshahi Medical College.
* For correspondence

Abstract
Objective: Breast lesions are heterogeneous diseases that consist of several distinct entities
with remarkably different characteristic features. The present study was conducted to assess
histopathological findings of breast lesions in excision biopsy samples.
Methods: This cross-sectional study was conducted in the Department of Pathology, Rajshahi
Medical College over a period of one year from July 2021 to June 2022. A total of 105 cases of
breast lesions were included in this study.
Result: Out of 105 cases of breast lesions studied, 59 cases (72%) were malignant and 46 cases
were benign lesions. Fibroadenoma (18 cases out of 46) was the most common benign lesion
followed by breast abscess (9 cases out of 46). On the other hand, invasive ductal carcinoma
was the highest occurred malignant tumour (59 cases, 56%). The age range of breast lesion was
15 to 75 yrs and highest incidence was in between 31-50 years (both benign and malignant).
Most of the breast lesions were occurred in left breast (62%).
Conclusion: Histopathological examination plays an important role in differentiating between
benign and malignant lesions. In the present study the most common benign breast lesion was
fibroadenoma and the most common malignant lesion was infiltrating ductal carcinoma. The

[Journal of Histopathology and Cytopathology, 2023 Jul; 7 (2):62-68]
Keywords: Histopathology, Malignant, Benign lesions, Breast lesion

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