Tag: p53

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jhc2025v9i1s4

Original Article

Expression of P53 in Clinically Diagnosed Solitary Thyroid Nodules

 *Ripa SP,1 Shilpi HK,2 Begum S3

 

  1. *Dr. Sabera Pervin Ripa, Assistant Professor, Department of Pathology, United Medical College, Shatarkul, Dhaka. dr.saberapervin@gmail.com.
  2. Harunur Rashid Khan Shilpi, Professor and ex-Head, Department of Pathology, Sir Salimullah Medical College, Dhaka.
  3. Shahnaj Begum, Professor and Head, Department of Pathology, Sir Salimullah Medical College, Dhaka.

 

*For correspondence

Abstract

Background: Solitary thyroid nodule has provoked increased concern owing to higher incidence of malignancy in it compared to multinodular goiter.Expression of p53 in solitary thyroid nodules has a significant impact on early diagnosis and better treatment strategy of thyroid carcinoma.

Method: Total 40 cases of solitary thyroid nodules were evaluated by immunohistochemical staining for mutant p53 expression. The study was performed in Sir Salimullah Medical College, Dhaka (from January, 2019 to December, 2020). Statistical analyses were carried out by using SPSS version 22 for Windows. A descriptive analysis was performed for all data.

Results: In this study, the mean age was 33.38 ± 13.11 and male to female ratio was 1:9. p53 expression was observed to be found more in relatively smaller tumor and most of the  differentiated tumors. Among malignant lesions, the predominant histologic type was papillary thyroid carcinoma (85%) including follicular variant and usual type. All carcinomas (100%) were well differentiated. Most of malignant lesions (92.6%) showed positive p53 expression.

Conclusion: Patients with p53 expression are related to malignant thyroid nodules. So, p53 immunoexpression is an important genetic marker for differentiating benign and malignant thyroid nodules.

 

[Journal of Histopathology and Cytopathology, 2025 Jan; 9 (1):20-29]

DOI: https://www.doi.org/10.69950/jhc2025v9i1s4

 

Keywords: Solitary thyroid nodule, p53

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jhc.2024.8.1.03

Journal of Histopathology and Cytopathology

January 2024 Volume 8 Issue 1

Original Contribution

Evaluation of Immunohistochemical Expression of p53 in Colorectal Carcinoma

1. *Dr. Mahfuza Jebun  Mouri; Lecturer, Department of Pathology, Shaheed Suhrawardy Medical College, Sher-E-Bangla Nagar, Dhaka.  mouri@gmail.com.
2. Professor Dr. Enamul Kabir, Professor, Department of Pathology, Popular Medical College, Dhaka.
3. Professor Dr. Shahnaj Begum, Professor, Department of Pathology, Sir Salimullah Medical College, Dhaka.

*For correspondence
Abstract
Background: The most common gastrointestinal malignancy is colorectal carcinoma and is a major cause of morbidity and mortality. In colorectal carcinoma the most frequently mutated gene is p53 tumor suppressor gene. Mutation of p53 gene gives rise to abnormal protein which can be easily detected by immunohistochemistry. Expression of mutant p53 protein has been associated with poor clinical outcome and increased risk of death due to increased aggressiveness of the disease.
Objective: The aim of the study was to see the clinicopathological correlation of mutant p53 expression in colorectal carcinoma.
Method: Total 50 paraffin embedded tissue blocks of histopathologically diagnosed cases of colorectal cancer were evaluated by immunohistochemical staining for mutant p53 expression. The study was performed in Sir Salimullah Medical College, Dhaka (from March, 2018 to February, 2020).
Results: Out of 50 patients studied, 29 cases (58%) expressed mutant p53 protein in the nucleus of malignant cells. There was significant association between  p53  protein expression and clinicopathologic variables such as age (<40 years vs >40 years, p=0.032), site of tumor (left vs right colon, p=0.028), pathological type (mucinous vs non mucinous, p=0.039), grade (a greater tendency towards poor differentiation, p= 0.039), advanced stage (both TNM and Dukes), whereas no significant association was found between mutant p53 protien expression and other parameters like gender and morphological types.
Conclusion: The results of this current study revealed that mutant p53 positive colorectal cancer tended to be related to a higher grade of malignancy, advanced tumor stage and mucinous morphology. The results of this current study revealed that mutant p53 positive colorectal cancer tended to be related to a higher grade of malignancy, advanced tumor stage and mucinous morphology. So, p53 is an important immunohistochemical marker for colorectal cancer patients.

[Journal of Histopathology and Cytopathology, 2024 Jan; 8 (1):10-18]

DOI: https://www.doi.org/10.69950/jhc.2024.v8.i1.03
Keywords: Colorectal cancer, p53, Immunohistochemistry
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