Category: Meetings and Events

Posted on

jhc.2024.8.1.05

Journal of Histopathology and Cytopathology
January 2024 Volume 8 issue 1

Original Contribution

Evaluation of Pediatric Common Solid Small Round Cell Tumors: An Immunohistochemical Study

1. Dr. Md. Shahrior Nahid, MBBS, MD(Pathology), Resident Medical Officer, Department of Pathology, National Institute of Laboratory Medicine and Referral Centre (NILMRC), Dhaka-1207. shahrior.nahid@gmail.com
2. Processor (Dr.) Ferdousy Begum, MBBS, MD (Pathology), Professor and Ex-Chairman, Department of Pathology, Bangabandhu Sheikh Mujib Medical University, Dhaka-1000.
3. Professor (Dr.) Mohammed Shahed Ali Jinnah, MBBS, MD(Pathology), Professor of Pathology, Director, National Institute of Laboratory Medicine and Referral Center, Sher-E-Bangla Nagar, Dhaka-1207.
4. Dr. Umama-Tun-Nesa Emita, MBBS, MD(Pathology), Pathologist, Khulna Medical College Hospital, Khulna.
5. Dr Md. Mahabub Alam, MBBS, MD (Pathology), Assistant Professor (Current Charge), Bashundhara Ad-din Medical College, Dhaka.
6. Dr. Arbin Siddiquea, MBBS, MD (Biochemistry), Lecturer, Department of Biochemistry, Shaheed Suhrawardy Medical College, Dhaka-1207.
7. Dr. Tasmina Anam, MBBS, MPhil (Immunology), Medical Officer, Department of Pathology, Bangabandhu Sheikh Mujib Medical University, Dhaka-1000.
⃰ For correspondence

Abstract
Background: Pediatric small round cell tumors (SRCTs) are diagnostically challenging lesions due to their primitive character.  With the rising incidence and having better treatment outcome as compared to the past, the categorization of SRCTs into definitive histological types is extremely important as individual tumor differs therapeutically and has separate prognostic significance. Immunohistochemistry (IHC) can play an important role here.
Objective: The present study was designed to evaluate the role of immunohistochemistry (IHC) in the differential diagnoses of pediatric SRCTs.
Results: In this study, various histomorphological types of pediatric SRCTs were identified in about 97% of cases with the aid of immunohistochemical stains. However, about 3% of cases remain unclassified even after immunohistochemical tests. The different morphological patterns were as follows; 24.4% rhabdomyosarcoma, 22.2% lymphoblastic lymphoma, 22.2% neuroblastoma, 22.2% soft tissue Ewing sarcoma, 4.44% Wilms Tumor, and 1.48% poorly differentiated synovial sarcoma.
Conclusion: Immunohistochemistry plays an important role as is evident from the present study and supported by many previous studies in categorizing undifferentiated or poorly differentiated small round cell tumors of childhood.

[Journal of Histopathology and Cytopathology, 2024 Jan; 8 (1):31-40]

DOI: https://www.doi.org/10.69950/jhc.2024.v8.i1.05
Keywords: Small round cell tumors (SRCTs), Immunohistochemistry (IHC)

Download full

Posted on

jhc.2024.8.1.03

Journal of Histopathology and Cytopathology

January 2024 Volume 8 Issue 1

Original Contribution

Evaluation of Immunohistochemical Expression of p53 in Colorectal Carcinoma

1. *Dr. Mahfuza Jebun  Mouri; Lecturer, Department of Pathology, Shaheed Suhrawardy Medical College, Sher-E-Bangla Nagar, Dhaka.  mouri@gmail.com.
2. Professor Dr. Enamul Kabir, Professor, Department of Pathology, Popular Medical College, Dhaka.
3. Professor Dr. Shahnaj Begum, Professor, Department of Pathology, Sir Salimullah Medical College, Dhaka.

*For correspondence
Abstract
Background: The most common gastrointestinal malignancy is colorectal carcinoma and is a major cause of morbidity and mortality. In colorectal carcinoma the most frequently mutated gene is p53 tumor suppressor gene. Mutation of p53 gene gives rise to abnormal protein which can be easily detected by immunohistochemistry. Expression of mutant p53 protein has been associated with poor clinical outcome and increased risk of death due to increased aggressiveness of the disease.
Objective: The aim of the study was to see the clinicopathological correlation of mutant p53 expression in colorectal carcinoma.
Method: Total 50 paraffin embedded tissue blocks of histopathologically diagnosed cases of colorectal cancer were evaluated by immunohistochemical staining for mutant p53 expression. The study was performed in Sir Salimullah Medical College, Dhaka (from March, 2018 to February, 2020).
Results: Out of 50 patients studied, 29 cases (58%) expressed mutant p53 protein in the nucleus of malignant cells. There was significant association between  p53  protein expression and clinicopathologic variables such as age (<40 years vs >40 years, p=0.032), site of tumor (left vs right colon, p=0.028), pathological type (mucinous vs non mucinous, p=0.039), grade (a greater tendency towards poor differentiation, p= 0.039), advanced stage (both TNM and Dukes), whereas no significant association was found between mutant p53 protien expression and other parameters like gender and morphological types.
Conclusion: The results of this current study revealed that mutant p53 positive colorectal cancer tended to be related to a higher grade of malignancy, advanced tumor stage and mucinous morphology. The results of this current study revealed that mutant p53 positive colorectal cancer tended to be related to a higher grade of malignancy, advanced tumor stage and mucinous morphology. So, p53 is an important immunohistochemical marker for colorectal cancer patients.

[Journal of Histopathology and Cytopathology, 2024 Jan; 8 (1):10-18]

DOI: https://www.doi.org/10.69950/jhc.2024.v8.i1.03
Keywords: Colorectal cancer, p53, Immunohistochemistry
Download full

Posted on

Executive Committees

Bangladesh Academy of Pathology

 

 

 

 

 

 

 

 

Convenor Committee 2025

Convenor: Professor Dr. M Shahab Uddin Ahamad
Member Secretary: Brig. Gen. (Retd) Prof. Dr. Sk Md. Jaynul Islam
Treasurer: Dr. Touhid Uddin Rupom
Members:
Prof. Dr. Ferdousy Begum
Professor Dr. Ruksana Jeba
Prof. Dr. Md. Mahmudul Huda (Himel)
Dr. Taslima Hossain
Dr. Shahnaz Pervin
Dr Nazneen Naher Aymon
Dr. Moh. Mahabubul Hoque
Md. Shahadat Hossain (Jewel)

Executive Committee 2024-2026

President: Professor Dr. Md. Nasimul Islam
President (Elect): Professor Dr. Shamiul Islam Sady
Vice president: Prof. Md. Zillur Rahman
General Secretary: Professor Dr. Shamim Akhter Mimi
Treasurer: Dr. Zubaida Bahroon Khan
President (recent past): Professor Md. Golam Mostafa
Joint Secretary: Dr. Prasun Biswas
Organizing Secretary: Dr. Mohammad Mahabubul Hoque
Office Secretary: Dr. Raquibul Hasan Kazal
Scientific Secretary: Dr. Md. Mainul Islam
Publication Secretary: Dr. Asaduzzaman

EC Members
Prof. Kazi Nishat Ara Begum
Professor Dr. Ruksana Jeba
Professor Dr. Kaniz Rasul
Prof. Md. Saidur Rahman
Professor Dr. Tareak Al Nasir
Dr. Farzana Rahman
Dr. SM Masud Alam
Dr. Mohammed Imran Hassan
Dr. Subrata Ray

Executive Committee 2022-2023

President:  Professor Dr. Md. Golam Mostafa
President Elect:  Professor Dr. Md. Nasimul Islam
Vice President:   Professor Dr. Ferdousy Begum
General Secretary: Professor Dr. Mohammed Shahed Ali Jinnah
Treasurer: Dr. Mohammad Masiur Rahman
Immediate Past President: Professor Ashim Ranjan Barua
Joint Secretary:  Dr.Raquibul Hasan Kazal
Scientific Secretary:  Dr. Mohammad Mahbubul Hoque
Publication Secretary: Dr. Md. Sadequel Islam Talukder

Executive Members:
Professor Dr. A Q M Abdul Hye
Professor Dr. M. Shahab Uddin Ahamad
Professor Dr. Shamim Akhter Mimi
Dr. Touhid Uddin Rupom
Dr. Taslima Hossain
Dr. Rubina Yasmin
Dr. Md.Imran Hassan
Dr. Zubaida Bahroon Khan
Dr. SaiyedaSinthia Karim
Dr. Subroto Roy
Dr. Prasun Biswas

Executive Committee 2019-2020

President: Professor Ashim Ranjan Barua
President Elect: Professor Md. Golam Mostafa
Vice President:  Professor Md. Shamiul Islam
General Secretary: Dr. AKM Nurul Kabir
Treasurer: Dr. Mashiur Rahman
Immediate Past President: Professor Kaniz Rasul
Joint Secretary: Dr. Md. Shahed Ali Jinnah
Scientific Secretary: Professor Dr. Md. Nasimul Islam
Publication Secretary: Dr. Md. Sadequel Islam Talukder
Members:
Professor Faruque Ahmed
Professor Enamul Kabir
Professor Md. Nowfel Islam
Dr. Mohammad Zillur Rahman
Dr. Kazi Nishat Ara Begum
Dr. Ferdousy Begum
Dr. Ruksana Jeba
Dr. Touhid Uddin Rupom
Dr. Md. Mahmudul Huda
Dr. Taslima Hossain
Dr. Shahab Uddin Ahmed

 

Executive Committee 2017-2018

President: Professor Kaniz Rasul
President Elect: Professor Ashim Ranjan Barua
Vice President: Professor Md. Nowfel Islam
General Secretary: Professor Md. Shamiul Islam
Treasurer: Dr. AKM Nurul Kabir
Immediate Past President: Professor Mohammad Kamal
Joint Secretary: Dr. Shamim Farooq (Titu)
Scientific Secretary: Dr. Md. Rezaul Karim Dewan
Publication Secretary: Dr. Md. Sadequel Islam Talukder
Members:
Professor Shah Monir Hossain
Professor AUM Muhsin
Professor Faruque Ahmed
Professor Md. Golam Mostafa
Professor Enamul Kabir
Dr. Mohammad Zillur Rahman
Dr. Kazi Nishat Ara Begum
Dr. Ferdousy Begum
Dr. Shamim Akhter Mimi
Dr. Shamima Ferdousi
Dr. Ruksana Jeba
Dr. Touhid Uddin Rupom
Dr. Md. Shahed Ali Jinnah
Dr. Md. Mahmudul Huda