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jhc.2024.8.1.05

Journal of Histopathology and Cytopathology
January 2024 Volume 8 issue 1

Original Contribution

Evaluation of Pediatric Common Solid Small Round Cell Tumors: An Immunohistochemical Study

1. Dr. Md. Shahrior Nahid, MBBS, MD(Pathology), Resident Medical Officer, Department of Pathology, National Institute of Laboratory Medicine and Referral Centre (NILMRC), Dhaka-1207. shahrior.nahid@gmail.com
2. Processor (Dr.) Ferdousy Begum, MBBS, MD (Pathology), Professor and Ex-Chairman, Department of Pathology, Bangabandhu Sheikh Mujib Medical University, Dhaka-1000.
3. Professor (Dr.) Mohammed Shahed Ali Jinnah, MBBS, MD(Pathology), Professor of Pathology, Director, National Institute of Laboratory Medicine and Referral Center, Sher-E-Bangla Nagar, Dhaka-1207.
4. Dr. Umama-Tun-Nesa Emita, MBBS, MD(Pathology), Pathologist, Khulna Medical College Hospital, Khulna.
5. Dr Md. Mahabub Alam, MBBS, MD (Pathology), Assistant Professor (Current Charge), Bashundhara Ad-din Medical College, Dhaka.
6. Dr. Arbin Siddiquea, MBBS, MD (Biochemistry), Lecturer, Department of Biochemistry, Shaheed Suhrawardy Medical College, Dhaka-1207.
7. Dr. Tasmina Anam, MBBS, MPhil (Immunology), Medical Officer, Department of Pathology, Bangabandhu Sheikh Mujib Medical University, Dhaka-1000.
⃰ For correspondence

Abstract
Background: Pediatric small round cell tumors (SRCTs) are diagnostically challenging lesions due to their primitive character.  With the rising incidence and having better treatment outcome as compared to the past, the categorization of SRCTs into definitive histological types is extremely important as individual tumor differs therapeutically and has separate prognostic significance. Immunohistochemistry (IHC) can play an important role here.
Objective: The present study was designed to evaluate the role of immunohistochemistry (IHC) in the differential diagnoses of pediatric SRCTs.
Results: In this study, various histomorphological types of pediatric SRCTs were identified in about 97% of cases with the aid of immunohistochemical stains. However, about 3% of cases remain unclassified even after immunohistochemical tests. The different morphological patterns were as follows; 24.4% rhabdomyosarcoma, 22.2% lymphoblastic lymphoma, 22.2% neuroblastoma, 22.2% soft tissue Ewing sarcoma, 4.44% Wilms Tumor, and 1.48% poorly differentiated synovial sarcoma.
Conclusion: Immunohistochemistry plays an important role as is evident from the present study and supported by many previous studies in categorizing undifferentiated or poorly differentiated small round cell tumors of childhood.

[Journal of Histopathology and Cytopathology, 2024 Jan; 8 (1):31-40]

DOI: https://www.doi.org/10.69950/jhc.2024.v8.i1.05
Keywords: Small round cell tumors (SRCTs), Immunohistochemistry (IHC)

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