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JHC 2023 January v7 i1 s4

Original Contribution

Role of FNAC and Core Needle Biopsy in the Diagnosis of Breast Lesions

1.*Dr. Anindita Sarkar, MD (Pathology), Assistant Professor (C.C), Pathology Department, Rajshahi Medical
College. abantica.16@gmail.com.
2. Prof. Dr. S. M. Asafudullah, MD (Pathology), Professor and Head of Department of Pathology, Rajshahi Medical
College.
3. Dr. Khadiza Khanam, MD (Pathology), Professor, Pathology Department, Rajshahi Medical College.
4. Dr. Rukhshana Akhter Jahan, MD (Pathology), Associate Professor, Pathology Department, Rajshahi Medical
College.
5. Dr. Tanshina Afrin, MD (Pathology), Assistant Professor (C.C), Pathology Department, Rajshahi Medical College.
6. Dr. Rebeka Sultana, MD (Pathology), Consultant, Islami Bank Hospital, Rajshahi.
*For correspondence

Abstract
Background: Though excision biopsy of breast lump is considered to be the gold standard method
for diagnosis, there should be an improved and definitive method for establishing an accurate
diagnosis of breast lesions prior to surgery. This study was carried out to evaluate the efficacy and
diagnostic performance of fine needle aspiration cytology (FNAC) and core needle biopsy (CNB)
in the preoperative assessment of breast lesions.
Methods: This cross-sectional study was conducted in the private diagnostic center in Rajshahi,
Bangladesh over a period of one year from January 2022 to December 2022.A total of 60 cases
were subjected to both FNAC and CNB from the same breast lesions included in this study.
Result: The age range of total 60 patients was 22-85 years with mean age of 42.18 ±SD 12.15
years. 38 patients had benign lesions and 22 had malignant tumors. Sensitivity, specificity, positive
predictive value, negative predictive value, and diagnostic accuracy for FNAC were 89.4%, 100%,
100%, 84.6%, and 93.3%, respectively in diagnosing carcinoma. CNB had sensitivity, specificity,
positive predictive value, negative predictive value, and diagnostic accuracy of 94.7%, 100%,
100%, 91.6% and 91.6% respectively. Both FNAC and CNB showed statistically significant
association.
Conclusion: Taking into account the benefits and outcomes, combined approach of FNAC and
CNB can provide accurate preoperative diagnosis of breast lesions and provide important
information for appropriate treatment

[Journal of Histopathology and Cytopathology, 2023 Jan; 7 (1):21-26]
Keywords: FNAC, Core needle biopsy (CNB), Breast lesion

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JHC 2023 January v7i 1s3

Original Contribution

Histopathological Analysis of Uterine Lesions in Hysterectomy Specimen at a Tertiary Hospital

1.*Dr. Md. Shahadat Hossain, Associate Professor& Head, Department of Pathology, AWMC,
Dhaka.dr.shossain@yahoo.com.
2. Dr. SK Salowa Sultana, Assistant professor, Department of Pathology, AWMC, Dhaka.
3. Dr. Shaikh Alamgir Hossain, Senior Consultant(Pathology), Bangladesh Secretariat Clinic, Dhaka
*For correspondence

Abstract
Background: The female genital tract is a hormone responsive system to a degree unmatched by
any other system in the body. The gross configuration of uterus changes dramatically throughout
life.The gynecological specimen forms the substantial proportion of work load in histopathology
laboratory. Hysterectomy is the most common major gynecological operation in the world which
can be done through either abdominal or vaginal routes.
Objective: To find the histopathological features of various lesions of uterine body and cervix,
their profile and distribution of different lesion in relation to age.
Method: This descriptive type of study was carried out with 808 patients who undergone
hysterectomy operation through either abdominal or vaginal routes. After fixation, necessary
blocks were obtained from the uterus that includes endometrium, myometrium, lower uterine
segment and cervix. The tissue pieces were then processed manually and histopathological slides
were made using hematoxylin and eosin stain.
Results: All of 808 cases, the most common type of hysterectomy was abdominal hysterectomy
comprising of 651 cases (80.57%) followed by vaginal hysterectomy comprising 157 cases
(19.43%). Most of the abdominal hysterectomy was done in 36-45 years age group and in older age
group most of the hysterectomy was done by vaginal route. Chronic cervicitis is the most common
cervical pathology in this study which was 58.42 %. Cervical intraepithelial neoplasia (CIN), mild
and moderate were 31(3.84%) cases and 10(1.24%) cases respectively and cervical cancer
(invasive squamous cell carcinoma) was found 11(1.35%) cases in which most of the cases
7(63.64%) were in between 46-50 years age group. Pathological lesion of body of uterus shows
most of the cases adenomyosis and leiomyoma which were 297(36.76 %) cases and 309 (38.24 %)
cases respectively and 7 (0.87%) patients had endometrial adenocarcinoma.
Conclusion: Uterine fibroids and adenomyosis were the most common benign conditions in
hysterectomy specimens in our community with peak incidence at fourth decade while cervical
cancer peaked at the same age group and endometrial adenocarcinoma peaked at fifth decade. At
the same time, vaginal hysterectomy was performed exclusively for utero-vaginal prolapse

[Journal of Histopathology and Cytopathology, 2023 Jan; 7 (1):12-20]
Keywords: Histopathology, Hysterectomy, chronic cervicitis

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JHC 2023 v7 i2 s11

Case Report

Primary Squamous Cell Carcinoma of Breast in a Lactating Mother: A Rare Case Report

1.*Dr. DM Arifur Rahman, Associate professor (Pathology), TMSS Medical College, Bogura.
arifurrahmandm@gmail.com
2. Dr. Rokhsana Sarmin, Junior Consultant (Surgery), 250 Bedded Mohammad Ali Hospital, Bogura.
*For correspondence

Abstract
We report a case of 32 years old woman diagnosed as primary squamous cell carcinoma during lactation, which is exquisitely rare. Histopathological examination confirms the diagnosis. Due torarity of the entity the diagnosis and management is challenging

[Journal of Histopathology and Cytopathology, 2023 Jul; 7 (2):119-122]
Keywords: Squamous cell carcinoma, Lactating mother

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