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JHC 2023 v7 i2 s10

Case Report

Coexistence of Psoriasis and Leprosy: A Rare Case Report of Long-standing Dermatological Conditions

1.*Dr. SM. Basitur Roshid, Assistant Professor, Department of Surgical Pathology, BIRDEM, Dhaka, Bangladesh.
dr.basitroshid@gmail.com
2. Dr. Fahmeeda Tasnim, MD Resident, Pathology, BIRDEM under BSMMU, Dhaka, Bangladesh.
3. Dr. Mohammad Mahabubul Hoque, Assistant Professor of Pathology, National Institute of Laboratory Medicine
and Referral Centre, Agargaon, Dhaka.
*For correspondence

Abstract
Psoriasis and leprosy are two distinct chronic dermatological conditions with unique clinical
features and pathogenesis. The coexistence of these two conditions in a single patient is extremely
rare and poses diagnostic and therapeutic challenges. We present a case report of a patient who
suffered from psoriasis for 20 years and subsequently developed leprosy, as confirmed by
histopathological examination. This case highlights the importance of considering concurrent
dermatological conditions in patients with long-standing psoriasis and emphasizes the need for a
multidisciplinary approach to diagnosis and management.

[Journal of Histopathology and Cytopathology, 2023 Jul; 7 (2):116-118]
Keywords: Psoriasis, Leprosy

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JHC 2023 v7 i2 s9

Case Report

STUMP of Prostate Gland – Case Report

1.*Dr. Afroza Begum, Associate Professor, Department of Pathology, Anwer Khan Modern Medical College.
afroza.mithila@gmail.com
2. Dr. Azfar Uddin Shaikh, Assistant Professor, Urology, Anwer Khan Modern Medical College
3. Prof. Mohammed Kamal, Chief Consultant, The Laboratory, Ex-Chairman and Head of the Department of
Pathology, BSMMU
*For correspondence
Abstract
Specialized stromal tumours of prostate includes stromal tumors of uncertain malignant potential
(STUMP) and stromal sarcoma. Florid Benign prostatic hyperplasia must be differentiated from
prostatic stromal neoplasia. Prostatic STUMPs may have significant overlap with florid stromal
hyperplasia. A case of prostatic STUMP is reported in this article. A 56 years old man presented
with dysuria. Ultrasonography and CT scan showed inhomogenous parenchyma and highly
suspicious lesion in posterior transition zone and postero-lateral peripheral zone of left lobe at mid
gland of prostate. Capsular invasion was absent. Core biopsy revealed nodular hyperplasia with
focal phyllodes like atypical stromal hyperplasia (STUMP). PSA level was 7.2 ng/ml. We should
observe the glandular epithelial neoplasia and stromal cells changes during histopathological
diagnosis because sarcomatouus changes in stromal cells is equally devastating as carcinoma

[Journal of Histopathology and Cytopathology, 2023 Jul; 7 (2):112-115]
Keywords: Stromal tumour of uncertain malignant potential (STUMP), Prostate specific antigen
(PSA), Ki67 (Proliferative index), PI-RADS, BPH (Benign prostatic hyperplasia)

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JHC 2023 July v7 i2 s8

Original Contribution

Role of Reticulin & Masson’s Trichrome Stains in Evaluation of Extent of
Fibrosis in Bone Marrow Biopsies: A Histochemical Study on 36 Cases of
Primary Myelofibrosis

1.*Dr. Sadia Afroz, Medical Officer, Department of Histopathology, National Institute of Cancer Research &
Hospital (NICRH), Mohakhali, Dhaka-1212, Bangladesh; sadiatoma2813@gmail.com
2. Dr. Bishnu Pada Dey, Associate Professor, Department of Pathology, BSMMU.
3. Dr. Rumana Yasmin, Assistant Professor, Department of Pathology, Dhaka Central International Medical College,
Dhaka, Bangladesh.
4. Dr. Evana Kabir, Specialist, Laboratory, United Hospital, Gulshan-2, Dhaka, Bangladesh
5. Dr. Syeeda Shiraj-Um-Mahmuda, Lecturer, Department of Pathology, Dhaka Medical College & Hospital, Dhaka.
6. Dr. Tasmia Islam, Specialist (Pathology), Square Hospital Limited, Dhaka-1205, Bangladesh.
7. Dr. Ummey Salma Shabnam, , Assistant Professor, Department of Histopathology, National Institute of Cancer
Research & Hospital (NICRH), Mohakhali, Dhaka-1212, Bangladesh.
8. Dr. A.K.M. Nurul Kabir, Professor, Department of Pathology, Bangabandhu Sheikh Mujib Medical University
(BSMMU), Shahbagh, Dhaka-1000, Bangladesh.
*For correspondence

Abstract
Background: Primary myelofibrosis (PMF) is a rare hematological malignancy with higher
mortality and morbidity due to progression of bone marrow fibrosis (BMF). The amount of bone
marrow reticulin and collagen fibrosis is detected by reticulin and Masson’s trichrome (MT) stains,
respectively. The study aimed to explore the pattern and degree of BMF in PMF cases with above
mentioned special stains along with conventional Hematoxylin& Eosin (H&E) stain.
Methods: Thirty-six histopathologically suggested or diagnosed cases of PMF were studied at the
Department of Pathology, BSMMU. Paraffin blocks of trephine biopsy specimens of the selected
cases were collected. H&E, reticulin and MT stains were applied on the re-cut sections. Extent of
fibrosis was assessed by examining the sections with each special stain using a proposed four
scaled semiquantitative bone marrow fibrosis (MF) grading systems. The cases were divided into
two groups. Patients having grade MF-0 to MF-1 were considered absent pathological BMF. Those
cases with MF-2 to MF-3 were encountered with present pathological BMF.
Results: In this study, 19 (52.8%) PMF cases had pathological BMF diagnosed by only H&E.
Moreover, thirty four (94.4%) patients had pathological BMF corresponding to MF-2 to MF-3
detected by special stains.
Conclusion: Significantly higher (p<0.05) detection of pathological BMF cases with use of
additional special stains recommends that, both reticulin and MT stains can be used routinely to
assess BMF properly according to special grading system.

[Journal of Histopathology and Cytopathology, 2023 Jul; 7 (2):103-111]
Keywords: Bone marrow fibrosis, Primary myelofibrosis, Reticulin fibrosis, Collagen fibrosis,
Reticulin stain, Masson’s trichrome stain, Hematoxylin & Eosin, Bone marrow fibrosis (MF) grade.

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