Tag: CD10

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jhc2026v10i2s3

Original
Stromal Expression of CD10 in Oral Squamous Cell Carcinoma and its Association with Histological Grade
*Hasnain M,1 Jeba R,2 Doly NJ,3 Hasan M,4 Nahar R,5 Nupur FP6

  1. *Dr. Monera Hasnain, MD (Pathology), Histopathologist, Department of Pathology, Mugda Medical College, Dhaka. drmonera0090@gmail.com. ORCID:https://orcid.org/0009-0000-1073-7039
  2. Dr. Ruksana Jeba, MD (Pathology), Professor and Head, Department of Pathology, Dhaka Medical College, Dhaka ORCID:https://orcid.org/0009-0003-3025-7309.
  3. Dr. Nusrat Jahan Doly, MD (Pathology), Assistant Surgeon, National Institute of Burn and Plastic Surgery, Dhaka. ORCID:https://orcid.org/0009-0009-0440-0056.
  4. Dr. Marufa Hasan, MD (Pathology), Assistant Professor (In situ), Department of Pathology, Mugda Medical College, Dhaka. ORCID:https://orcid.org/0009-0006-6681-2468.
  5. Dr. Rejwana Nahar, MD (Pathology), Assistant Professor, Department of Pathology, Mugda Medical College, Dhaka. ORCID:https://orcid.org/0009-0005-1883-7794.
  6. Dr. Farjana Pervin Nupur, MD (Pathology), Assistant Professor, Department of Pathology, Dhaka Medical College, Dhaka. ORCID:https://orcid.org/0009-0009-5416-1073.

*For correspondence
Abstract
Background:Oral squamous cell carcinoma (OSCC) is one of the most frequently encountered malignancies of the oral cavity worldwide. Identification of reliable molecular markers may improve prognostic assessment and individualized management of affected patients.
Methods: This cross-sectional observational study was performed in the Department of Pathology, Dhaka Medical College, Dhaka, between September 2022 and August 2024. A total of 56 histopathologically confirmed OSCC cases, including 40 resected specimens and 16 mucosal biopsies, were enrolled according to predefined inclusion and exclusion criteria. Hematoxylin and eosin-stained slides and paraffin-embedded tissue blocks were reviewed in all cases. Immunohistochemical staining for CD10 and Masson trichrome staining were carried out on formalin-fixed paraffin-embedded tissue sections. Stromal CD10 expression was assessed and correlated with histological grade. Statistical analysis was performed using SPSS version 23, and a p-value below 0.05 was considered statistically significant.
Results: Most patients belonged to the 41–60 years age group (46.4%). The mean age was 61.0 ± 12.84 years, and males were more frequently affected than females with a ratio of 2.1:1. Positive stromal CD10 immunoreactivity was detected in 45 (80.4%) cases. The highest positivity was observed in poorly differentiated tumors (100%), followed by moderately differentiated tumors (96.3%) and well differentiated tumors (44.4%). The association between CD10 expression and histological grade was statistically significant (p=0.00001).
Conclusion: The present study demonstrated a significant relationship between stromal CD10 expression and increasing histological grade of OSCC. Therefore, CD10 may serve as a useful adjunctive marker for predicting aggressive biological behavior in oral squamous cell carcinoma.
[Journal of Histopathology and Cytopathology, 2026 Jul; 10 (2):96-103]
DOI: https://www.doi.org/10.69950/jhc.2026.10.2.3
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JHC2023v7i1s6

Original Contribution

Stromal Expression of CD10 in invasive Ductal Carcinoma and its relationship
with ER, PR and HER2-neu Status

1.*Dr. Farah Imrana, MD (Histopathology), Assistant Professor, BIHS General Hospital. 125/1Darus
Salam, Mirpur, Dhaka.. farahdr02@gmail.com
2. Dr. Md. Shahriar Mamun, Assistant Professor (cc), Department of Pathology, Satkhira Medical College.
3. Dr. SM Moshadeq Hossain, Assistant Professor, Pathology, Rajshahi Medical College.
4. Dr. Alimul Hassan, Clinical Pathologist, Rangpur Medical College Hospital.

*For correspondence

Abstract
Background: Ductal carcinoma is a common type of breast cancer that starts in cells of milk ducts
and can enhance the risk of developing invasive breast cancer in the long run. The study aimed to
evaluate the stromal expression of CD10 in Invasive Ductal Carcinoma and its relationship with
ER, PR, and HER-2 status.
Methods: This cross-sectional study was carried out in the Department of Pathology, Rajshahi
Medical College, Rajshahi, from July 2017 to December 2018, to evaluate the expression of
stromal CD10 in invasive breast carcinoma and to correlate with ER, PR, HER 2/neu status in
mastectomy or lumpectomy specimen. A total of 50 cases of mastectomy or lumpectomy
specimens will be taken that were received in the Department. Samples were selected by the
purposive sampling technique.
Results: In the present study, out of total 50 cases, most of the study subjects that is 17 (34%)
belonged to the age group of 51-60 years. Estrogen receptor were positive in 29(58.0%) cases,
progesterone receptor was positive in 16(32.0%) cases. The association between estrogen receptor
status with stromal CD10, all the 16 (100.0%) CD 10 strong positive cases were negative for
estrogen receptor. In CD10 negative group, almost all 28 (96.6%) cases were positive for estrogen
receptor. The difference was statistically significant (p<0.05).
Conclusion: Substantial knowledge regarding stromal contribution to cancer progression could
help researchers to identify particular signals which could lead to the revelation of new therapeutic
targets in the future.

[Journal of Histopathology and Cytopathology, 2023 Jan; 7 (1):36-44]
Keywords: Ductal carcinoma, CD10, Estrogen receptor, Progesterone receptor, Her-2, Invasive

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JHC 2023 January v7 i1 s5

Original Contribution

Evaluation of Stromal CD10 Expression and its Correlation with other Clinicopathological Factors in Invasive Breast Carcinoma

1.*Dr. Farah Imrana, MD (Histopathology), Assistant Professor, BIHS General Hospital. 125/1Darus
Salam, Mirpur, Dhaka. farahdr02@gmail.com
2. Dr. Md. Shahriar Mamun, Assistant Professor (cc), Department of Pathology, Satkhira Medical College.
3. Dr. SM Moshadeq Hossain, Assistant Professor, Pathology, Rajshahi Medical College.
4. Dr. Alimul Hassan, Lecturer, Department of Pathology, Pabna Medical College.
*For correspondence

Abstract
Background: Expression of stromal CD10 was considerably remarked with metastasis of lymph
node and higher tumor grade. CD10 is a useful independent prognostic indicator which is
necessary to include in routine histopathology report
Objective: The intent of the study was to investigate the expression of stromal CD10 in invasive
breast carcinoma.
Methods: This cross sectional study was carried out in the department of Pathology, Rajshahi
Medical College, Rajshahi, during July 2017 to December 2018, to evaluate the expression of
stromal CD10 in invasive breast carcinoma and to correlate with ER, PR status in mastectomy
specimen. A total of 50 cases of mastectomy or lumpectomy specimens will be taken that are
received in the Department. Samples were selected by the purposive sampling technique.
Result: In the present study, out of 50 cases stromal CD 10 was found to be strong positive in
13(36.1%), weak positive in 9(25%) and negative in 14(38.9%) cases. Regarding the association
between tumor grade with stromal CD10 it was observed that 9 (56.3%) out of total 16 CD 10
strong positive cases, 3 (60.0%) out of five CD10 weak positive and 26 (89.7%) out of 29 CD 10
negative were grade I tumor. Seven (43.8%) were grade II tumor in the strong positive group, 2
(40.0%) in weak positive group and none in negative group. In this series it was observed that
maximum 38 (76.0%) cases were grade II tumors followed by 09 (18.0%) cases were grade I and
03 (6.0%) cases were grade III tumor. The difference was statistically significant (p<0.05) between
tumor grade with stromal CD 10 expression.
Conclusion: This study was undertaken to detect the expression of stromal CD10 in invasive
breast carcinoma in mastectomy specimen. Tumor grade was significantly (p<0.05) associated with
stromal CD 10.

[Journal of Histopathology and Cytopathology, 2023 Jan; 7 (1):27-35]
Keywords: Stromal, CD10, Carcinoma

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