Original Contribution
Histopathological Analysis of Uterine Lesions in Hysterectomy Specimen at a Tertiary Hospital
1.*Dr. Md. Shahadat Hossain, Associate Professor& Head, Department of Pathology, AWMC,
Dhaka.dr.shossain@yahoo.com.
2. Dr. SK Salowa Sultana, Assistant professor, Department of Pathology, AWMC, Dhaka.
3. Dr. Shaikh Alamgir Hossain, Senior Consultant(Pathology), Bangladesh Secretariat Clinic, Dhaka
*For correspondence
Abstract
Background: The female genital tract is a hormone responsive system to a degree unmatched by
any other system in the body. The gross configuration of uterus changes dramatically throughout
life.The gynecological specimen forms the substantial proportion of work load in histopathology
laboratory. Hysterectomy is the most common major gynecological operation in the world which
can be done through either abdominal or vaginal routes.
Objective: To find the histopathological features of various lesions of uterine body and cervix,
their profile and distribution of different lesion in relation to age.
Method: This descriptive type of study was carried out with 808 patients who undergone
hysterectomy operation through either abdominal or vaginal routes. After fixation, necessary
blocks were obtained from the uterus that includes endometrium, myometrium, lower uterine
segment and cervix. The tissue pieces were then processed manually and histopathological slides
were made using hematoxylin and eosin stain.
Results: All of 808 cases, the most common type of hysterectomy was abdominal hysterectomy
comprising of 651 cases (80.57%) followed by vaginal hysterectomy comprising 157 cases
(19.43%). Most of the abdominal hysterectomy was done in 36-45 years age group and in older age
group most of the hysterectomy was done by vaginal route. Chronic cervicitis is the most common
cervical pathology in this study which was 58.42 %. Cervical intraepithelial neoplasia (CIN), mild
and moderate were 31(3.84%) cases and 10(1.24%) cases respectively and cervical cancer
(invasive squamous cell carcinoma) was found 11(1.35%) cases in which most of the cases
7(63.64%) were in between 46-50 years age group. Pathological lesion of body of uterus shows
most of the cases adenomyosis and leiomyoma which were 297(36.76 %) cases and 309 (38.24 %)
cases respectively and 7 (0.87%) patients had endometrial adenocarcinoma.
Conclusion: Uterine fibroids and adenomyosis were the most common benign conditions in
hysterectomy specimens in our community with peak incidence at fourth decade while cervical
cancer peaked at the same age group and endometrial adenocarcinoma peaked at fifth decade. At
the same time, vaginal hysterectomy was performed exclusively for utero-vaginal prolapse
[Journal of Histopathology and Cytopathology, 2023 Jan; 7 (1):12-20]
Keywords: Histopathology, Hysterectomy, chronic cervicitis
Full Article