Category: Journal

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JHC 2023 v7 i2 s9

Case Report

STUMP of Prostate Gland – Case Report

1.*Dr. Afroza Begum, Associate Professor, Department of Pathology, Anwer Khan Modern Medical College.
afroza.mithila@gmail.com
2. Dr. Azfar Uddin Shaikh, Assistant Professor, Urology, Anwer Khan Modern Medical College
3. Prof. Mohammed Kamal, Chief Consultant, The Laboratory, Ex-Chairman and Head of the Department of
Pathology, BSMMU
*For correspondence
Abstract
Specialized stromal tumours of prostate includes stromal tumors of uncertain malignant potential
(STUMP) and stromal sarcoma. Florid Benign prostatic hyperplasia must be differentiated from
prostatic stromal neoplasia. Prostatic STUMPs may have significant overlap with florid stromal
hyperplasia. A case of prostatic STUMP is reported in this article. A 56 years old man presented
with dysuria. Ultrasonography and CT scan showed inhomogenous parenchyma and highly
suspicious lesion in posterior transition zone and postero-lateral peripheral zone of left lobe at mid
gland of prostate. Capsular invasion was absent. Core biopsy revealed nodular hyperplasia with
focal phyllodes like atypical stromal hyperplasia (STUMP). PSA level was 7.2 ng/ml. We should
observe the glandular epithelial neoplasia and stromal cells changes during histopathological
diagnosis because sarcomatouus changes in stromal cells is equally devastating as carcinoma

[Journal of Histopathology and Cytopathology, 2023 Jul; 7 (2):112-115]
Keywords: Stromal tumour of uncertain malignant potential (STUMP), Prostate specific antigen
(PSA), Ki67 (Proliferative index), PI-RADS, BPH (Benign prostatic hyperplasia)

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JHC 2023 July v7 i2 s8

Original Contribution

Role of Reticulin & Masson’s Trichrome Stains in Evaluation of Extent of
Fibrosis in Bone Marrow Biopsies: A Histochemical Study on 36 Cases of
Primary Myelofibrosis

1.*Dr. Sadia Afroz, Medical Officer, Department of Histopathology, National Institute of Cancer Research &
Hospital (NICRH), Mohakhali, Dhaka-1212, Bangladesh; sadiatoma2813@gmail.com
2. Dr. Bishnu Pada Dey, Associate Professor, Department of Pathology, BSMMU.
3. Dr. Rumana Yasmin, Assistant Professor, Department of Pathology, Dhaka Central International Medical College,
Dhaka, Bangladesh.
4. Dr. Evana Kabir, Specialist, Laboratory, United Hospital, Gulshan-2, Dhaka, Bangladesh
5. Dr. Syeeda Shiraj-Um-Mahmuda, Lecturer, Department of Pathology, Dhaka Medical College & Hospital, Dhaka.
6. Dr. Tasmia Islam, Specialist (Pathology), Square Hospital Limited, Dhaka-1205, Bangladesh.
7. Dr. Ummey Salma Shabnam, , Assistant Professor, Department of Histopathology, National Institute of Cancer
Research & Hospital (NICRH), Mohakhali, Dhaka-1212, Bangladesh.
8. Dr. A.K.M. Nurul Kabir, Professor, Department of Pathology, Bangabandhu Sheikh Mujib Medical University
(BSMMU), Shahbagh, Dhaka-1000, Bangladesh.
*For correspondence

Abstract
Background: Primary myelofibrosis (PMF) is a rare hematological malignancy with higher
mortality and morbidity due to progression of bone marrow fibrosis (BMF). The amount of bone
marrow reticulin and collagen fibrosis is detected by reticulin and Masson’s trichrome (MT) stains,
respectively. The study aimed to explore the pattern and degree of BMF in PMF cases with above
mentioned special stains along with conventional Hematoxylin& Eosin (H&E) stain.
Methods: Thirty-six histopathologically suggested or diagnosed cases of PMF were studied at the
Department of Pathology, BSMMU. Paraffin blocks of trephine biopsy specimens of the selected
cases were collected. H&E, reticulin and MT stains were applied on the re-cut sections. Extent of
fibrosis was assessed by examining the sections with each special stain using a proposed four
scaled semiquantitative bone marrow fibrosis (MF) grading systems. The cases were divided into
two groups. Patients having grade MF-0 to MF-1 were considered absent pathological BMF. Those
cases with MF-2 to MF-3 were encountered with present pathological BMF.
Results: In this study, 19 (52.8%) PMF cases had pathological BMF diagnosed by only H&E.
Moreover, thirty four (94.4%) patients had pathological BMF corresponding to MF-2 to MF-3
detected by special stains.
Conclusion: Significantly higher (p<0.05) detection of pathological BMF cases with use of
additional special stains recommends that, both reticulin and MT stains can be used routinely to
assess BMF properly according to special grading system.

[Journal of Histopathology and Cytopathology, 2023 Jul; 7 (2):103-111]
Keywords: Bone marrow fibrosis, Primary myelofibrosis, Reticulin fibrosis, Collagen fibrosis,
Reticulin stain, Masson’s trichrome stain, Hematoxylin & Eosin, Bone marrow fibrosis (MF) grade.

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JHC 2023 v7 i2 s7

Original Contribution

Histomorphological Pattern of Vocal Cord Lesions in a Tertiary Care Hospital

1.*Dr Naila Awal, Assistant Professor, Department of Pathology, Green Life Medical College, Dhaka.
nailaawal@gmail.com
2. Dr Md Saidur Rahman, Professor and Head, Department of Pathology, Sher-e-Bangla Medical College, Barishal.
3. Dr Subrata Ray, Assistant Professor, Department of Pathology, Sher-e-Bangla Medical College, Barishal.
4. Dr Abirvab Naha, Assistant Professor, Department of Otolaryngology- Head and neck Surgery, Bangabandhu
Sheikh Mujib Medical University, Dhaka.
5. Dr Rumana Yasmin, Assistant Professor, Department of Pathology, Dhaka Central International Medical College,
Dhaka.
6. Dr Lyzu Sharmin, Assistant Professor, Histopathology department, National Institute of Cancer Research and
Hospital, Dhaka.
7. Dr Md. Shafiqul Alam, Associate Professor, Radiology and Imaging Department, Monno Medical College,
Manikgonj.
*For correspondence

Abstract
Background: Voice is the most important component for human to communicate their ideas,
emotion and personality with the outside world. Vocal cord lesion is one of the most common
problems in the Otolaryngology Department. Even the smallest swelling on the free edge of vocal
cord can cause voice disturbances and has significant social and psychological impact. The aim of
our study was to find out the frequencies of the vocal cord lesions and to assess the various
histomorphological characteristics of these lesions among the patients of various age groups in
Bangladeshi population.
Methods: A retrospective, record review (secondary data analysis) study was carried out among
2054 patients who underwent surgery in Green Life hospital for any vocal cord lesion between the
period of 2011 to 2021. The data was collected from an electronic database from Histopathology
Department of Green Life Hospital.
Result: The study population consists of total 2054 cases with male and female ratio of 3.8:1. The
age of the patient was between 5 to 95 years and the majority of the patients (27%) were presented
with 3rd to 4th decades. Male (79%) were commonly affected than female (21%). Male patients
showed higher percentage in 40-50 years age group (21%), while female patient showed higher
percentage in 18-40 years age group (13%).
A total of 63 (3.1 %) cases were non neoplastic, 1966 (95.7%) cases were neoplastic, and 25 (1.2
%) cases were diagnosed as premalignant. The most common vocal cord lesion was vocal cord
polyp (81.3%) followed by invasive squamous cell carcinoma 272 cases (13.2%).
Conclusion: The histopathological examination of vocal cord lesion is the gold standard diagnostic
tool to evaluate voice disorders. The early diagnosis should be done carefully to evaluate
underlying pathology for better management

[Journal of Histopathology and Cytopathology, 2023 Jul; 7 (2):95-102]
Keywords: Vocal cord, Histopathology

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