Original Contribution
Immunohistochemical Evaluation of Ki67 Expression in Premalignant and Malignant Esophageal Lesions – Study of 54 Cases in a Tertiary Care Hospita
1. *Dr. Shifayat Sultana, Assistant Professor, Department of Pathology, Central Medical College, Cumilla.
shifayat.sultana.ss@gmail.com
2. Dr. Syeda Sadia Afrin, Lecturer, Department of Pathology, Dhaka Medical College, Dhaka.
3. Dr. Zubaida Bahroon Khan, Associate Professor, Department of Pathology, Dhaka Medical College, Dhaka.
4. Dr. Shirin Gull Zabin, Assistant Professor, Department of Pathology, Dhaka Medical College, Dhaka.
5. Dr. Rumana Afrin Sweety, Assistant Professor, Department of Pathology, Marks Medical College, Dhaka.
6. Dr. Md. Ariful Islam, Assistant Professor, Department of Pathology, Monowara Sikder Medical College,
Shariatpur.
7. Dr. Nazma Shaheen, Assistant Professor, Department of Pathology, Gonoshasthaya Samaj Vittik Medical College,
Dhaka.
8. Dr. Fatima Tuj Jahra, Assistant Professor, Department of Pathology, Aichi Medical College, Dhaka.
9. Professor Dr. Ruksana Jeba, Professor and Head, Department of Pathology, Dhaka Medical College, Dhaka.
10. Professor Dr. Rezaul Karim Dewan, Professor and Head, Department of Pathology, Greenlife Medical College,
Dhaka.
*For correspondence
Abstract
Background: In Bangladesh esophageal carcinoma is the leading malignant condition. Mortality
rate of esophageal cancer is very high. Like other malignancies, early detection offers the best
prognosis for esophageal carcinoma. Regular endoscopic and histologic surveillance have become
standard procedure for follow up of patients with premalignant lesions. But sometimes
histomorphological diagnosis on routine biopsies can be challenging for pathologist. Several
studies showed that positive Ki67 expression is significantly associated with higher grade of
esophageal lesions and is a potential prognostic marker.
Objectives: The aim of the present study was to evaluate Ki67 expression in each
histopathological category and to investigate the relationship of Ki67 with premalignant and
malignant esophageal lesions.
Methods: This study was a cross sectional study, carried out at the department of Pathology in
Dhaka Medical College and Hospital from March 2018 to February 2020. Total 54 cases of
esophageal biopsy were included in this study. They were divided in maligant and premalignant
category. All obtained samples were selected for routine histopathological study and
immunostaining for Ki67 was done in formalin fixed paraffin embedded tissue.
Results: Most of the patients were male and mean age was 55.04 (±15.48) years. Squamous cell
carcinoma was the most common malignancy seen in (26 cases) 48.15 % of patients and Barrett’s
esophagus was common (13 cases, 24.07%) premalignant lesion. Ki67 expression was found
statistically significant (p<0.05) when correlated with histomorphologic grading of premalignant
and malignant lesions. Calculation result of malignant and premalignant category as a whole
should be stated.
Conclusion: Ki67 expression positively correlates with histomorphologic grading of premalignant
and malignant esophageal lesions.
[Journal of Histopathology and Cytopathology, 2023 Jan; 7 (1):3-11]
Keywords: Barrett’s esophagus, esophageal carcinoma, Ki67
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