Journal of Histopathology and Cytopathology

January 2024 Volume 8 Issue 1

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Case Report

Swyer Syndrome with Gonadoblastoma: A Case Report

1. *Dr. Tasnim Binte Ahmed, Histopathologist, Department of Pathology, Mugda Medical College, Dhaka. ahmedtussy@gmail.com
2. Dr. Muhammad Enamul Haque, Senior Consultant, Department of Gynae & Obstetrics. Sir Salimullah Medical College, Dhaka. 3. Dr. Naila Huq, Professor & Head, Department of Pathology,Mugda Medical College, Dhaka.
*For correspondence

Abstract 
Background: Swyer syndrome is a condition of pure gonadal dysgenesis with 46, XY karyotype. These patients have female external phenotype and usually presented with primary amenorrhea. Detailed history, clinical, radiological and hormonal evaluation, karyotyping and histopathology are needed for diagnosis. Due to the presence of Y chromosomes these patients have streak gonads with increased risk of development of gonadoblastoma. Early diagnosis of Swyer syndrome followed by prophylactic gonadectomy is very important.
Case presentation: A 19-year-old female presented with the complaints of primary amenorrhea. The clinical, radiological, hormonal assessment and karyotyping test made the diagnosis of Swyer syndrome. The histopathological examination revealed left sided streak gonad and right sided gonadoblastoma.
Conclusion: Swyer syndrome is a rare form of disorders of sexual development. As there is high chance of gonadal malignancy, these patients should be counseled for preventive bilateral salpingo-oophorectomy

[Journal of Histopathology and Cytopathology, 2024 Jan; 8 (1):65-68]
DOI: https://www.doi.org/10.69950/jhc.2024.v8.i1.09

Keywords: Swyer syndrome, Gonadal dysgenesis, Gonadoblastoma.

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