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jhc.2026.10.1.2

Journal of Histopathology and Cytopathology

Official Journal of Bangladesh Academy of Pathology

Vol 10, No 1, January 2026

Expression of Cyclin D1 in Gastric Adenocarcinoma and its Association with Staging
Lubna NT,1 Jeba R,2 Rana MS,3 Khan RR,4 Islam MM,5 Kabir E,6 *Badhan RE7

Abstract
Background: Gastric cancer is a major global health concern, ranking as the 5th most common malignancy and the 3rd leading cause of cancer-related deaths worldwide, with 783,000 deaths reported in 2018 (GLOBOCAN). Over 70% of gastric cancer cases occur in developing countries. Cyclin D1, a cell cycle regulatory protein, is implicated in various oncogenic processes, including tumor progression, invasion, and metastasis. Its overexpression has potential utility in predicting tumor behavior and guiding individualized therapy. This study aimed to assess the expression of cyclin D1 in histologically diagnosed gastric adenocarcinoma and its association with tumor stage.
Methods: A cross-sectional observational study was conducted in the Department of Pathology, Dhaka Medical College, from March 2019 to February 2022. Fifty-one cases of histologically confirmed gastric adenocarcinoma were evaluated. Routine hematoxylin and eosin staining and immunohistochemistry for cyclin D1 were performed. Clinical and demographic data were recorded, and statistical analysis was done to determine associations.
Results: The mean age of patients was 57.67±12.49 years, with a male predominance (M: F = 2.4:1). Cyclin D1 expression was positive in 33 cases (64.7%). Of these, 76.5% were in T3 stage and 93.8% in N3 stage. Cyclin D1 positivity was more frequent in advanced tumor and nodal stages.
Conclusion: Cyclin D1 expression was significantly associated with higher tumor and nodal stages in gastric adenocarcinoma. Its overexpression may serve as a prognostic biomarker and aid in risk stratification and therapeutic decision-making.

[Journal of Histopathology and Cytopathology, 2026 Jan; 10 (1):4-16]
DOI: https://www.doi.org/10.69950/jhc.2026.10.1.2
Keywords: Cyclin D1, Gastric adenocarcinoma, Immunohistochemistry, Tumor stage, Carcinoma progression

  1. Nur A Tasnim Lubna, Lecturer, Department of Pathology, Sher-E-Bangla Medical College, Barishal. tasnim.sbmc@gmail.com
  2. Ruksana Jeba, Professor and Head, Department of Pathology, Dhaka Medical College, Dhaka. Ruksanajeba67@gmail.com
  3. Md. Samsul Arafin Rana, Registrar (Hepatology), Sher-E-Bangla Medical College Hospital, Barishal. rana.mmc44@gmail.com
  4. Rizwana Rahman Khan, Assistant Professor, Department of Pathology Dhaka Medical College, Dhaka drizwanasbmc@gmail.com
  5. Mohammad Mazharul Islam, Lecturer, Department of Pathology Dhaka Medical College, Dhaka, mazharscc21@gmail.com
  6. Evana Kabir, Specialist (Histopathology), Lab Medicine, United Hospital Limited Gulsan 2, Dhaka. evanakabir1990@gmail.com
  7. *Dr. Raisa Enayet Badhan, Medical officer, Department of Microbiology, National Institute of Burn and Plastic Surgery, Dhaka. raisabadhan@gmail.com

*For correspondence

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