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jhc2025v9i1s4

Original Article

Expression of P53 in Clinically Diagnosed Solitary Thyroid Nodules

 *Ripa SP,1 Shilpi HK,2 Begum S3

 

  1. *Dr. Sabera Pervin Ripa, Assistant Professor, Department of Pathology, United Medical College, Shatarkul, Dhaka. dr.saberapervin@gmail.com.
  2. Harunur Rashid Khan Shilpi, Professor and ex-Head, Department of Pathology, Sir Salimullah Medical College, Dhaka.
  3. Shahnaj Begum, Professor and Head, Department of Pathology, Sir Salimullah Medical College, Dhaka.

 

*For correspondence

Abstract

Background: Solitary thyroid nodule has provoked increased concern owing to higher incidence of malignancy in it compared to multinodular goiter.Expression of p53 in solitary thyroid nodules has a significant impact on early diagnosis and better treatment strategy of thyroid carcinoma.

Method: Total 40 cases of solitary thyroid nodules were evaluated by immunohistochemical staining for mutant p53 expression. The study was performed in Sir Salimullah Medical College, Dhaka (from January, 2019 to December, 2020). Statistical analyses were carried out by using SPSS version 22 for Windows. A descriptive analysis was performed for all data.

Results: In this study, the mean age was 33.38 ± 13.11 and male to female ratio was 1:9. p53 expression was observed to be found more in relatively smaller tumor and most of the  differentiated tumors. Among malignant lesions, the predominant histologic type was papillary thyroid carcinoma (85%) including follicular variant and usual type. All carcinomas (100%) were well differentiated. Most of malignant lesions (92.6%) showed positive p53 expression.

Conclusion: Patients with p53 expression are related to malignant thyroid nodules. So, p53 immunoexpression is an important genetic marker for differentiating benign and malignant thyroid nodules.

 

[Journal of Histopathology and Cytopathology, 2025 Jan; 9 (1):20-29]

DOI: https://www.doi.org/10.69950/jhc2025v9i1s4

 

Keywords: Solitary thyroid nodule, p53