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jhc2025v9i1s8

Original Article

Histopathological Study of Clinically Suspected Marjolin Ulcer at a Specialized Major Burn Centre in Bangladesh

 

*Asaduzzaman,1 Datta T,2 Khandkar T,3  Chowdhury MA4

 

 

  1. *Dr. Asaduzzaman, Associate Professor of Pathology, National Institute of Burn and Plastic Surgery, Dhaka. dr.asad37@gmail.com
  2. Tanusree Datta, Junior Consultant (Current Charge), National Institute of Burn and Plastic Surgery, Dhaka
  3. Tahmina Khandkar, Junior Consultant, Paediatrics, National Institute of Burn and Plastic Surgery, Dhaka
  4. Mehdi Ashik Chowdhury, Associate Professor of Pathology, Tairunnessa Memorial Medical College.

 

*For correspondence

Abstract

Background: Marjolin ulcer is a malignant transformation arising from chronic ulcers or scars from previously traumatized tissues that occur usually after burns. This study aims to study the histopathological profile of a suspected Marjolin ulcerat a major burn center in Bangladesh.

Methods: A retrospective analysis of all suspected Marjolin ulcer patients presented at theNational Institute of Burn and Plastic Surgery, Dhaka, Bangladesh from 2020 to 2024 was done. A total of 92 patients of all age groups were included in the study.

Results: Most of the patients were between 31-60 years with an overall male preponderance. The most common cause for Marjolin ulcer was burn scars followed by trauma. Lower extremities were found to be the most predominant site. The latency period for the development of Marjolin ulcer was more than 20 years in most of the cases. Squamous cell carcinoma was the most common histological subtype.

Conclusion: Chronic non-healing ulcers or scars from previous trauma that do not respond to treatment should be carefully examined for malignant transformation. Histopathologically, these Marjolin ulcers in most of cases are squamous cell carcinoma.

[Journal of Histopathology and Cytopathology, 2025 Jan; 9 (1):55-63]

DOI: https://www.doi.org/10.69950/jhc2025v9i1s8

 

Keywords: Burn; Marjolin Ulcer; Basal cell carcinoma; Squamous Cell Carcinoma