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jhc2026v10i2s8


Original
Vimentin Expression in Infiltrating Ductal Carcinoma NOS of Breast and its Association with Clinicopathological Characteristics
*Tahsin KN,1 Doly NJ,2 Rashid HO,3 Yeamin MA,4 Sultana S,5 Khan RR,6 Jeba R7

  1. Dr. Kazi Nafisa Tahsin, MD (Pathology), Medical Officer, Department of Histopathology, National Institute of Burn and Plastic Surgery, Dhaka, kazinafisa29@gmail.com. ORCID: https://orcid.org/0009-0007-2549-7606
  2. Dr. Nusrat Jahan Doly, MBBS, MD (Pathology), Medical Officer, Department of Histopathology, National Institute of Burn and Plastic Surgery, Dhaka, doctornusratjahan1990@gmail.com. ORCID: https://orcid.org/0009-0009-0440-0056
  3. Dr. Md. Abdullah Yeamin, MBBS, MD (Pathology), Lecturer, Jashore Medical College, Jashore, peyal4794@gmail.com. ORCID: https://orcid.org/0009-0002-9119-720X
  4. Dr. Harum Or Rashid, MBBS, MD (Pathology), Lecturer, Department of Pathology, Sirajganj Medical College, Sirajganj, drharunorrashidjewel@gmail.com. ORCID: https://orcid.org/0009-0003-6229-8041
  5. Dr. Shahana Sultana, MBBS, MD (Pathology), Assistant Professor, Green life Medical College, Dhaka, shahanashova935@gmail.com. ORCID: https://orcid.org/0009-0000-6533-3947
  6. Dr. Rizwana Rahman Khan, MBBS, MD (Pathology), Associate Professor, Department of Pathology, Dhaka Medical College, Dhaka, drizwanasbmc@gmail.com. ORCID: https://orcid.org/0000-0001-9207-4063
  7. Dr. Ruksana Jeba, MBBS, MD (Pathology), Professor and Head, Department of Pathology, Dhaka Medical College, Dhaka, ruksanajeba67@gmail.com. ORCID: https://orcid.org/0009-0003-3025-7309

*For correspondence
Abstract
Background: Despite advances in therapy, breast cancer remains the leading cause of cancer related deaths among women worldwide. The most common invasive subtype, Infiltrating Ductal Carcinoma (IDC), often presents at advanced stages. Rapid progression and therapeutic resistance contribute to such poor outcomes. Vimentin, a cytoskeletal protein linked to epithelial-mesenchymal transition (EMT), is associated with aggressive tumor behavior, poor prognosis, and drug resistance, making it a potential prognostic and predictive marker for IDC.
Objectives: To evaluate vimentin expression in IDC-NOS of the breast and its association with clinicopathological features.
Methods: This cross-sectional observational study was conducted in the Department of Pathology, Dhaka Medical College, from September 2022 to August 2024. Sixty histopathologically diagnosed IDC-NOS cases were examined. Immunohistochemistry for vimentin was performed on formalin-fixed, paraffin-embedded tissues at AI Khan Lab Ltd., Dhaka. Associations with clinicopathological features were analyzed; p < 0.05 was considered statistically significant.
Results: Vimentin expression was positive in 43.3% of cases. It was significantly higher in Grade 3 tumors (65.4%, p < 0.001) and in the triple-negative subtype (57.7%, p = 0.003). No significant association was observed with age, tumor size, stage, or lymphovascular invasion.
Conclusion: Vimentin expression showed significant associations with aggressive breast cancer phenotypes, particularly higher grade and TNBC subtype. These findings suggest that vimentin may serve as a useful supplementary prognostic marker to aid in risk stratification and management of breast cancer.
[Journal of Histopathology and Cytopathology, 2026 Jul; 10 (2):136-145]
DOI: https://www.doi.org/10.69950/jhc.2026.10.2.8

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jhc2026v10i2s7


Original
Vimentin Expression in Renal Cell Carcinoma and It’s Association with Histological Grade and Pathological Stage
*Adhikary P,1 Begum S,2 Ferdous JN,3 Saha AK,4 Papry A,5 Emita U6

  1. *Dr. Priyanka Adhikary, MBBS, MD (Pathology), Junior consultant, Department of Pathology, Pirojpur District Hospital, Pirojpur, Bangladesh. priyanka003@gmail.com. ORCID: https://orcid.org/0009-0007-0148-2733.
  2. Dr. Shahnaj Begum, Professor & Head, Department of Pathology, Sir Salimullah Medical College, Dhaka, Bangladesh. dr.shahnaj68@gmail.com ORCID: https://orcid.org/0009-0005-8210-1327.
  3. Dr. Jesmin Naz Ferdous, MBBS, MD(Pathology), Professor, Department of Pathology, Sir Salimullah Medical College, Dhaka, Bangladesh.  limaf888@gmail.com ORCID: https://orcid.org/0009-0009-5412-3958.
  4. Dr. Anjishu Kumar Saha, MSc (Statistics) Statistician, Khulna University, Khulna Bangladesh. anjishusaha9@gmail.com ORCID: https://orcid.org/0009-0004-2122-123X.
  5. Dr. Afsana Papry, MBBS, MD, Lecturer, Department of Pathology, Sir Salimullah Medical College, Dhaka, Bangladesh. afsana.papry121.ap@gmail.com ORCID: https://orcid.org/0009-0003-6601-3955.
  6. Dr. Umama-Tun-Nesa Emita, MBBS, MD, Pathologist, Khulna Medical College and Hospital, Khulna, Bangladesh. emita.rmc@gmail.com

*For correspondence
Abstract
Introduction: Renal cell carcinoma (RCC) is the most common type of kidney cancer and the incidence of it has been steadily increasing over the past few years. The precise prediction of prognosis is very important for planning an effective therapy and follow-up visits. There are some established prognostic factors, like- histological grade, pathological stage and tumor subtypes, but the tumor behavior is difficult to predict and may show different outcome. Immunohistochemical study of several molecular markers may be helpful in this regard.
Objectives: The aim of the present study was to evaluate the expression of vimentin in renal cell carcinoma and to determine it’s association with histological types, grades and pathological  stages.
Methods: This cross-sectional observational study was conducted with 35 cases of RCC for a period of 2 years in Department of Pathology, Sir Salimullah Medical College, Dhaka. In all of histopathologically diagnosed cases of renal cell carcinoma immunohistochemical staining was done. The collected data were organized and analyzed using Statistical Package for the Social Sciences (SPSS) version 25. Chi-square test, Fisher’s exact test and Spearman’s correlation test were used for statistical analysis. A p value of < 0.05 was considered as significant.
Results: The mean age of the study population was 53.17 ± 11.95 years & large number of patients (57.1%) were belonged to 41-60 years age group with male predominance (74.3%). Most of the patients (91.4%) presented with hematuria followed by 74.3% had flank pain and 51.4% had palpable renal mass. The most common subtype was clear cell carcinoma (68.6%) followed by papillary carcinoma (22.8%), chromophobe (5.7%) and collecting duct carcinoma (2.9%). Stage pT1 (40.0%) was the most frequent diagnosis of RCC followed by stage pT2 (34.3%) & Stage pT3 (25.7%). Grade 2 RCC was the most frequent diagnosis (40.6%) followed by 28.1% grade 3, 18.8% grade 4 and 12.5% grade 1 RCC. Vimentin expression was negative in chromophobe RCC but other subtypes showed variable degree of cytoplasmic expression of vimentin. Vimentin IHC expression was significantly high (≥8) with increase in the pathological T stage & WHO/ISUP grade of RCC (p-value 0.038 and 0.03 respectively).
Conclusion: Immunohistochemical expression of vimentin showed statistically significant association with the pathological T stage (pT) and histological grades (G) of renal cell carcinoma. Routine use of vimentin expression in conjunction with histopathological grading and staging may provide prognostic information to predict disease progression.
[Journal of Histopathology and Cytopathology, 2026 Jul; 10 (2):125-135]
DOI: https://www.doi.org/10.69950/jhc.2026.10.2.7

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jhc2026v10i2s6


Original
Histomorphological Pattern of Sellar and Suprasellar Region Tumor in Tertiary Level Hospital of Bangladesh
*Shirin S,1 Jeba R,2 Wahid SR,3 Nupur FP,4 Jannat MR5

  1. *Dr. Sadia Shirin, MD (Pathology), Lecturer, Department of Pathology, Dhaka Medical College, Dhaka, sadiashirin77@gmail.com. ORCID:https://orcid.org/0009-0006-6879-4208
  2. Dr. Ruksana Jeba, MD (Pathology), Professor and Head, Department of Pathology, Dhaka Medical College, Dhaka.ORCID: https://orcid.org/0009-0003-3025-7309
  3. Dr. Sadia Refat Wahid, MD (Pathology), Assistant Professor, Department of Pathology, Dhaka Medical College, Dhaka.ORCID: https://orcid.org/0009-0004-3821-7747
  4. Dr. Farjana Pervin Nupur, MD (Pathology), Assistant Professor, Department of Pathology, Dhaka Medical College, Dhaka, ORCID: https://orcid.org/0009-0009-5416-1073
  5. Dr. Mst Rubeyatul Jannat, MD (Pathology), Lecturer, Department of Pathology and Pharmacology, School of Medicine, IMU University, Kuala Lumpur, Malaysia. ORCID: https://orcid.org/0009-0007-8252-4375

*For correspondence

Abstract
Background: Sellar and suprasellar region tumors comprise a wide spectrum of neoplastic and non-neoplastic lesions with overlapping clinical and radiological features. Histopathological evaluation remains the gold standard for accurate diagnosis. The aim of this study was to observe the histomorphological pattern of sellar and suprasellar region tumors in a tertiary level hospital of Bangladesh.
Methods: This cross-sectional observational study was conducted in the Department of Pathology, Dhaka Medical College, from April 2023 to March 2024. A total of 125 radiologically diagnosed sellar and suprasellar lesions were included by purposive sampling. Tissue specimens obtained by biopsy were processed routinely and stained with hematoxylin and eosin for histopathological examination. Data were analyzed using SPSS version 24.0.
Results: Pituitary adenoma was the most common tumor, accounting for 72.8% of cases, followed by craniopharyngioma (12%) and meningioma (6.4%). The mean age of patients was 34±17.2 years, with slight male predominance (53.6%). Most tumors occurred in the 31–40 years age group. Headache was the most common presenting symptom (48.8%), and most tumors measured >4 cm radiologically. Adamantinomatous craniopharyngioma was the predominant subtype, mainly affecting children.
Conclusion: Pituitary adenoma was the predominant sellar and suprasellar tumor in this study. Histopathological examination remains essential for accurate diagnosis and differentiation of these lesions for appropriate management.
[Journal of Histopathology and Cytopathology, 2026 Jul; 10 (2):118-124]
DOI: https://www.doi.org/10.69950/jhc.2026.10.2.6
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