Tag: Histopathology

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jhc2026v10i2s2

Original
Lupus Nephritis; an Unrevealed Morbidity in Bangladeshi Population- A Clinical and Histomorphological Study
*Imrana,1 Islam SJ,2 Rahman TS,3 Azad A4

  1. *Dr Farah Imrana, Associate Professor, Department of Pathology, BIHS General Hospital, Mirpur-1, Dhaka. farahdr02@gmail.com. ORCID: https://orcid.org/0009-0005-0941-9638
  2. Brig Gen. Prof SK Jaynul Islam, Senior Consultant, Pathology, BIRDEM Hospital, Shahbag, Dhaka. ORCID: https://orcid.org/0000-0002-0388-4441
  3. Dr. Tanzila Subrina Rahman, Associate Professor, Pathology, Rajshahi Medical College. ORCID: https://orcid.org/0009-0000-2373-4996
  4. Dr. Afroza Azad, Associate Professor, Department of Clinical Biochemistry, BIHS General Hospital, Mirpur-1, Dhaka. ORCID: https://orcid.org/0009-0005-8579-6128

Abstract
Background: Systemic lupus erythematosus (SLE) is a chronic autoimmune disorder with multi-organ involvement. SLE affect on kidneys, mostly referred to as Lupus nephritis (LN) is of special interest for three reasons. First, lupus nephritis is one of the commonest types of organ involvement in this disorder, affecting as up to 45% of all patients with SLE. Second, it presents with a great variety of clinical and histopathological findings and thirdly, it greatly affects the morbidity and mortality of SLE patients. Thus, LN is one of the most serious SLE complications and the clinicopathological findings of LN are responsible for the ultimate prognosis of SLE. But these findings show geographical variation. Data on LN of Bangladeshi patients are rare in  literature and most of them describe mostly clinical features rather than the histomorphologic findings.
Objectives: To evaluate demographic, clinical, laboratory and histomorphological characteristics of LN patient and analyze correlations across different INS/RPS 2003 classes.
Method: A prospective, cross-sectional study was conducted at a tertiary diagnostic center in Dhaka from July 2024 to June 2025. Total fifty clinically diagnosed SLE cases with renal involvement were included in this study. The study group were underwent renal core biopsy. Histological evaluation and direct immunofluorescence (DIF) study were done on each specimen. Each case was classified according to the International Society for Nephrology/Renal Pathology Society (ISN/RPS) 2003 LN classification system and compared with the clinical, biochemical and immunological findings.
Results: The mean age was 28.3±12.2 years (range: 9-70), with female predominance (M:F ratio 1:4.5). Proteinuria was the leading presentation (96%), followed by hematuria (56%). ISN/RPS classification revealed Class IV as most frequent (40%), followed by Class III (26%). Class II (22%), Class V (08%) and Class I (04%). Proliferative LN (Class III/IV) exhibited crescent formation (30%), wire loop formation (34%) and necrotizing change (36%). Full house Immunofluorescence deposits were present in 85% of evaluable cases. Higher activity and chronicity indices were observed in Class IV lesions, correlating with worse renal function.
Conclusion: Class IV LN was the predominant and most severe subtype, strongly associated with adverse clinical, biochemical and histological features. Early renal biopsy and clinicopathological correlation remain indispensable for prognosis and therapeutic planning in Bangladeshi patients.
[Journal of Histopathology and Cytopathology, 2026 Jul; 10 (2):86-95]
DOI: https://www.doi.org/10.69950/jhc.2026.10.2.2
*For correspondence
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jhc.2026.10.1.8

Journal of Histopathology and Cytopathology

Official Journal of Bangladesh Academy of Pathology

Vol 10, No 1, January 2026

Histopathologic Findings of Breast Lesions and It’s Association with Corresponding Radiologic Findings.

*Datta T,1 Asaduzzaman,2 Ray TK,3 Hoque MM4

Abstract
Background: Invasive breast carcinoma is one of the most common carcinoma in women. Breast Imaging-Reporting and Data System (BI-RADS) classification besides histopathology has become an important tool for evaluation of malignant breast diseases. The purpose of this study is to assess the similarity between radiological and histopathological findings and illustrate the predictive value in the BI-RADS category.
Methods: This is a retrospective study, done at National Institute of Burn and Plastic Surgery, Dhaka from January 2023 to December 2023, included those patients who had radiological examination with BI-RADS categories 3, 4 and 5 followed by histopathological examination to confirm the diagnosis based on breast core biopsy and excision specimen within 1 year. The clinico-radiologic features were correlated with the histopathologic results using the chi- square test. The scoring system was designed based on the significant predictive features of malignancy, and its diagnostic performance was compared with that of the Breast Imaging-Reporting and Data System (BI-RADS) category.
Result: Among 111 cases, by histopathological diagnosis, malignancy was found in 54 cases (48.6%) and benign was found in 57 cases (51.4%). BI-RADS scoring category 3,4 and 5 cases were 51(45.9%), 26(23.4%) and 34(30.6%) respectively. P-value from Chi-square test shows strong association of malignancy with age ≥50, post-menopause and higher BI-RADS categories like 4 and 5. Overall, the breast lesions evaluated by BI-RADS classification have a sensitivity of 94.48%, specificity of 43.14%, a PPV of 63.9% and a NPV of 88%.
Conclusion: A strong association was found between BI-RADS score 4,5 and histopathologically diagnosed malignant lesion.

[Journal of Histopathology and Cytopathology, 2026 Jan; 10 (1):63-70]
DOI: https://www.doi.org/10.69950/jhc.2026.10.1.8

Keywords: Breast Lesion, BI-RADS, Histopathology, Association.

  1. *Dr. Tanusree Datta, MBBS, MD (Pathology), Assistant Professor, Pathology Department, National Institute of Burn and Plastic Surgery, Dhaka. tanusreebsmmu89@gmail.com.
  2. Dr. Asaduzzaman, MBBS, MD (Pathology), Associate Professor, Pathology Department, National Institute of Burn and Plastic Surgery, Dhaka.
  3. Dr. Major Tapan Kumar Ray, MBBS, FCPS Trainee Officer, Combined Military Hospital, Dhaka.
  4. Dr. Mohammad Mahabubul Hoque, MBBS, MD (Pathology), M. Med, Associate Professor, Pathology Department, National Institute of Laboratory Medicine and Referral Centre, Dhaka.

*For correspondence
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jhc2025v9i1

 

Front Cover PDF
Index PDF
Inside Back Cover PDF
Editorial Board PDF

Contents

Editorial

1. Red Meat: A Potential Carcinogen to Human
Rahman DA

Original Contributions

2. Association of E-cadherin Expression with Histopathological Grades and Clinical Stages of Laryngeal Squamous Cell Carcinoma

Tayeb M, Mimi SA, Kamal MS, Snigdha SS

3. Expression of Estrogen Receptor and Progesterone Receptor in Malignant Epithelial Ovarian Tumors
Shams S, Das R, Saha S

4. Expression of P53 in Clinically Diagnosed Solitary Thyroid Nodules
Ripa SP, Shilpi HK, Begum S

5. Determination of Mast Cell Density in Urothelial Carcinoma of Urinary Bladder and its Relation with Grading and Invasiveness
Wahid SR, Asafudullah SM, Khatun MM, Momin NN, Shirin S

 6. Expression of Ki-67 and AgNOR in Primary Central Nervous System (CNS) Tumours
Nahar A, Islam MN,Kabir E

7. Computed Tomography Guided Fine Needle Aspiration Cytology of Mass Lesions of Lung: A Study of 56 Cases
Wahed A, Islam N, Hossain MM, Nurunnabi M

8. Histopathological Study of Clinically Suspected Marjolin Ulcer at a Specialized Major Burn Centre in Bangladesh
Asaduzzaman,Datta T, Khandkar T, Chowdhury MA

Other

9. Information for Contributors