Tag: Histopathology

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jhc.2024.v8.i2.3


Editorial
Original Contribution

Histomorphological Patterns of Lesions in Lymph Node Biopsies in a Tertiary Care Hospital

*Sarkar A,1 Khanam K,2 Afrin T3

  1. *Dr. Anindita Sarkar, MD (Pathology), Assistant Professor (C.C), Department of Pathology, Rajshahi Medical College, Rajshahi, abantica.16@gmail.com.
  2. Khadiza Khanam, MD (Pathology), Professor and Head, Department of Pathology, Rajshahi Medical College, Rajshahi.
  3. Tanshina Afrin, MD (Pathology), Assistant Professor (C.C), Department of Pathology, Rajshahi Medical College, Rajshahi.

* For Correspondence

Abstract
Background: Lymphadenopathy is one of the most common presentations of inflammatory and neoplastic disorders. Detailed assessment is required to reveal an underlying pathology. Clinical features along with radiology images may not be sufficient for diagnosis of lymph node enlargement. Hence, lymph node biopsy has become a mandatory tool to arrive at a definitive diagnosis.
Methods: This cross-sectional retrospective study was conducted in the Department of Pathology, Rajshahi Medical College over a period of one year from July 2022 to June 2023. A total of 130 cases of lymph node biopsies were included in this study as the study subjects purposively. Specimen of tissue was fixed with 10% formalin and stained with haematoxyline and eosin stain, followed by histopathological examination. Statistical analysis was performed using Microsoft Excel.
Result: A total of 130 lymph node biopsies were studied with ages ranging from 13 to 72 years. Most of the cases (54%) belonged to 21-40 years. Female patients were 52% and male patients were 48%. Reactive hyperplasia was the commonest lesion accounting for 37% of cases (48 cases), followed by metastatic deposits showed in 36 cases (28%).Reactive hyperplasia was common in early age group while 69% of metastatic deposits were found in age group above 40 years. Duct cell carcinoma was the commonest metastatic carcinoma (42%) in this present study.
Conclusion: To establish the causes of lymphadenopathy, lymph node biopsy plays an important role. It is less expensive than other tests when investigating the cause of enlarged lymph nodes.

[Journal of Histopathology and Cytopathology, 2024 Jul; 8 (2):84-90]
DOI: https://www.doi.org/10.69950/jhc.2024.v8.i2.3
Keywords: Lymphadenopathy, Biopsy, Histopathology, Lymph nodes.
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JHC 2023 January v7i 1s3

Original Contribution

Histopathological Analysis of Uterine Lesions in Hysterectomy Specimen at a Tertiary Hospital

1.*Dr. Md. Shahadat Hossain, Associate Professor& Head, Department of Pathology, AWMC,
Dhaka.dr.shossain@yahoo.com.
2. Dr. SK Salowa Sultana, Assistant professor, Department of Pathology, AWMC, Dhaka.
3. Dr. Shaikh Alamgir Hossain, Senior Consultant(Pathology), Bangladesh Secretariat Clinic, Dhaka
*For correspondence

Abstract
Background: The female genital tract is a hormone responsive system to a degree unmatched by
any other system in the body. The gross configuration of uterus changes dramatically throughout
life.The gynecological specimen forms the substantial proportion of work load in histopathology
laboratory. Hysterectomy is the most common major gynecological operation in the world which
can be done through either abdominal or vaginal routes.
Objective: To find the histopathological features of various lesions of uterine body and cervix,
their profile and distribution of different lesion in relation to age.
Method: This descriptive type of study was carried out with 808 patients who undergone
hysterectomy operation through either abdominal or vaginal routes. After fixation, necessary
blocks were obtained from the uterus that includes endometrium, myometrium, lower uterine
segment and cervix. The tissue pieces were then processed manually and histopathological slides
were made using hematoxylin and eosin stain.
Results: All of 808 cases, the most common type of hysterectomy was abdominal hysterectomy
comprising of 651 cases (80.57%) followed by vaginal hysterectomy comprising 157 cases
(19.43%). Most of the abdominal hysterectomy was done in 36-45 years age group and in older age
group most of the hysterectomy was done by vaginal route. Chronic cervicitis is the most common
cervical pathology in this study which was 58.42 %. Cervical intraepithelial neoplasia (CIN), mild
and moderate were 31(3.84%) cases and 10(1.24%) cases respectively and cervical cancer
(invasive squamous cell carcinoma) was found 11(1.35%) cases in which most of the cases
7(63.64%) were in between 46-50 years age group. Pathological lesion of body of uterus shows
most of the cases adenomyosis and leiomyoma which were 297(36.76 %) cases and 309 (38.24 %)
cases respectively and 7 (0.87%) patients had endometrial adenocarcinoma.
Conclusion: Uterine fibroids and adenomyosis were the most common benign conditions in
hysterectomy specimens in our community with peak incidence at fourth decade while cervical
cancer peaked at the same age group and endometrial adenocarcinoma peaked at fifth decade. At
the same time, vaginal hysterectomy was performed exclusively for utero-vaginal prolapse

[Journal of Histopathology and Cytopathology, 2023 Jan; 7 (1):12-20]
Keywords: Histopathology, Hysterectomy, chronic cervicitis

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JHC 2023 v7 i2 s7

Original Contribution

Histomorphological Pattern of Vocal Cord Lesions in a Tertiary Care Hospital

1.*Dr Naila Awal, Assistant Professor, Department of Pathology, Green Life Medical College, Dhaka.
nailaawal@gmail.com
2. Dr Md Saidur Rahman, Professor and Head, Department of Pathology, Sher-e-Bangla Medical College, Barishal.
3. Dr Subrata Ray, Assistant Professor, Department of Pathology, Sher-e-Bangla Medical College, Barishal.
4. Dr Abirvab Naha, Assistant Professor, Department of Otolaryngology- Head and neck Surgery, Bangabandhu
Sheikh Mujib Medical University, Dhaka.
5. Dr Rumana Yasmin, Assistant Professor, Department of Pathology, Dhaka Central International Medical College,
Dhaka.
6. Dr Lyzu Sharmin, Assistant Professor, Histopathology department, National Institute of Cancer Research and
Hospital, Dhaka.
7. Dr Md. Shafiqul Alam, Associate Professor, Radiology and Imaging Department, Monno Medical College,
Manikgonj.
*For correspondence

Abstract
Background: Voice is the most important component for human to communicate their ideas,
emotion and personality with the outside world. Vocal cord lesion is one of the most common
problems in the Otolaryngology Department. Even the smallest swelling on the free edge of vocal
cord can cause voice disturbances and has significant social and psychological impact. The aim of
our study was to find out the frequencies of the vocal cord lesions and to assess the various
histomorphological characteristics of these lesions among the patients of various age groups in
Bangladeshi population.
Methods: A retrospective, record review (secondary data analysis) study was carried out among
2054 patients who underwent surgery in Green Life hospital for any vocal cord lesion between the
period of 2011 to 2021. The data was collected from an electronic database from Histopathology
Department of Green Life Hospital.
Result: The study population consists of total 2054 cases with male and female ratio of 3.8:1. The
age of the patient was between 5 to 95 years and the majority of the patients (27%) were presented
with 3rd to 4th decades. Male (79%) were commonly affected than female (21%). Male patients
showed higher percentage in 40-50 years age group (21%), while female patient showed higher
percentage in 18-40 years age group (13%).
A total of 63 (3.1 %) cases were non neoplastic, 1966 (95.7%) cases were neoplastic, and 25 (1.2
%) cases were diagnosed as premalignant. The most common vocal cord lesion was vocal cord
polyp (81.3%) followed by invasive squamous cell carcinoma 272 cases (13.2%).
Conclusion: The histopathological examination of vocal cord lesion is the gold standard diagnostic
tool to evaluate voice disorders. The early diagnosis should be done carefully to evaluate
underlying pathology for better management

[Journal of Histopathology and Cytopathology, 2023 Jul; 7 (2):95-102]
Keywords: Vocal cord, Histopathology

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