Category: Journal

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jhc2026v10i2s6


Original
Histomorphological Pattern of Sellar and Suprasellar Region Tumor in Tertiary Level Hospital of Bangladesh
*Shirin S,1 Jeba R,2 Wahid SR,3 Nupur FP,4 Jannat MR5

  1. *Dr. Sadia Shirin, MD (Pathology), Lecturer, Department of Pathology, Dhaka Medical College, Dhaka, sadiashirin77@gmail.com. ORCID:https://orcid.org/0009-0006-6879-4208
  2. Dr. Ruksana Jeba, MD (Pathology), Professor and Head, Department of Pathology, Dhaka Medical College, Dhaka.ORCID: https://orcid.org/0009-0003-3025-7309
  3. Dr. Sadia Refat Wahid, MD (Pathology), Assistant Professor, Department of Pathology, Dhaka Medical College, Dhaka.ORCID: https://orcid.org/0009-0004-3821-7747
  4. Dr. Farjana Pervin Nupur, MD (Pathology), Assistant Professor, Department of Pathology, Dhaka Medical College, Dhaka, ORCID: https://orcid.org/0009-0009-5416-1073
  5. Dr. Mst Rubeyatul Jannat, MD (Pathology), Lecturer, Department of Pathology and Pharmacology, School of Medicine, IMU University, Kuala Lumpur, Malaysia. ORCID: https://orcid.org/0009-0007-8252-4375

*For correspondence

Abstract
Background: Sellar and suprasellar region tumors comprise a wide spectrum of neoplastic and non-neoplastic lesions with overlapping clinical and radiological features. Histopathological evaluation remains the gold standard for accurate diagnosis. The aim of this study was to observe the histomorphological pattern of sellar and suprasellar region tumors in a tertiary level hospital of Bangladesh.
Methods: This cross-sectional observational study was conducted in the Department of Pathology, Dhaka Medical College, from April 2023 to March 2024. A total of 125 radiologically diagnosed sellar and suprasellar lesions were included by purposive sampling. Tissue specimens obtained by biopsy were processed routinely and stained with hematoxylin and eosin for histopathological examination. Data were analyzed using SPSS version 24.0.
Results: Pituitary adenoma was the most common tumor, accounting for 72.8% of cases, followed by craniopharyngioma (12%) and meningioma (6.4%). The mean age of patients was 34±17.2 years, with slight male predominance (53.6%). Most tumors occurred in the 31–40 years age group. Headache was the most common presenting symptom (48.8%), and most tumors measured >4 cm radiologically. Adamantinomatous craniopharyngioma was the predominant subtype, mainly affecting children.
Conclusion: Pituitary adenoma was the predominant sellar and suprasellar tumor in this study. Histopathological examination remains essential for accurate diagnosis and differentiation of these lesions for appropriate management.
[Journal of Histopathology and Cytopathology, 2026 Jul; 10 (2):118-124]
DOI: https://www.doi.org/10.69950/jhc.2026.10.2.6
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jhc2026v10i2s5


Original
Immunohistochemical Expression of Extracellular Matrix Metalloproteinase Inducer (EMMPRIN/CD147) in Renal Cell Carcinoma and Its Association with Histological Grade and Pathological Stage
*Mahmud S,¹ Bhuiyan AZ,2  Hossain SA,3 Yasmin R,4  Saha MK,5 Masud MR,6 Shakila J,7  Afrin S8

  1. *Dr. SMA Mahmud, MD (Pathology), Assistant Professor, Department of Pathology, National Institute of Laboratory Medicine and Referral Center, Dhaka. mahmudmoon@gmail.com. ORCID:https://orcid.org/ 0009-0001-8975-2406
  2. Dr. ARM Zakaria Bhuiyan, MD (Pathology), Lecturer, Department of Pathology, Mymensingh Medical College, Mymensingh. ORCID:https://orcid.org/0009-0007-9374-6854.
  3. Dr. Shaikh Alamgir Hossain, MD (Pathology), Professor, Ex-Head Department of Pathology, Mymensingh Medical College, Mymensingh.
  4. Dr. Rubina Yasmin, MD (Pathology), Associate Professor, Department of Pathology, Mymensingh Medical College, Mymensingh. ORCID:https://orcid.org/0009-0005-4011-7056.
  5. Dr. Mridul Kumar Saha, MD (Pathology), Assistant Professor, Department of Pathology, Manikganj Medical College, Manikganj. ORCID:https://orcid.org/0009-0007-2079-7757.
  6. Dr. Md. Rakibul Islam Masud, FCPS (Radiotherapy), Radiotherapist, Department of Radiotherapy, MMCH, Mymensingh. ORCID:https://orcid.org/0009-0005-9509-1375.
  7. Dr. Jobaida Shakila, MBBS, Ex Assistant Registrar, Department of Gynaecology and Obstetrics, Delta Hospital Limited, Dhaka. ORCID:https://orcid.org/0009-0008-0778-
  8. Dr. Sadia Afrin, MBBS, Army Medical College, Jashore . ORCID:https://orcid.org/0009-0002-5326-3413. 

*For correspondence
Abstract
Background: Renal cell carcinoma (RCC) is the commonest malignant epithelial tumor of kidney. Histological grade and stage are major prognostic indicators; however, additional biomarkers may improve prognostic assessment. EMMPRIN/CD14 is associated with tumor invasion, angiogenesis, and metastasis. The aim of this study is to evaluate immunohistochemical expression of EMMPRIN/CD147 in RCC and determine its association with histological grade and pathological stage.
Methods: This cross-sectional study included 40 nephrectomy specimens diagnosed as RCC. Histological grading was done according to WHO/ISUP system and staging by AJCC TNM classification. Immunohistochemical staining for EMMPRIN/CD147 was performed and scored by intensity and proportion of stained cells.
Results: Clear cell RCC was the commonest subtype (67.5%). High EMMPRIN expression was observed in 27 (67.5%) cases. Strong membranous and cytoplasmic positivity was more frequent in higher grade and advanced stage tumors. Significant association was found between EMMPRIN expression and histological grade and pathological stage (p<0.05).
Conclusion: EMMPRIN/CD147 high expression is associated with aggressive behavior of RCC and may be a useful prognostic biomarker.
[Journal of Histopathology and Cytopathology, 2026 Jul; 10 (2):111-117]
DOI: https://www.doi.org/10.69950/jhc.2026.10.2.5

 

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jhc2026v10i2s4


Original
Spectrum of Hepatic Lesions Diagnosed by Image-Guided Cytology and Core Needle Biopsy: A Retrospective Clinicopathological Study
*Quruni MO,1 Hossain MS,2 Afrin SS,3 Saha MK,4 Alam SN,5 Nupur FP,6 Jahan PA7
 

  1. *Dr. Md Oyes Quruni, MD (Pathology), Assistant Professor and Head, Department of Pathology, Tangail Medical College, Tangail. oyesquruni@gmail.com. ORCID: https://orcid.org/0009-0004-9184-3173.
  2. Dr. Md. Shahadat Hossain, MD (Pathology), Lecturer, Department of Pathology, Dhaka Medical College, Dhaka. ORCID: https://orcid.org/0009-0003-4384-4684.
  3. Dr. Syeda Sadia Afrin, MD (Pathology) Assistant Professor, Department of Pathology, Dhaka Medical College, Dhaka. ORCID: https://orcid.org/0009-0005-7257-3583.
  4. Dr. Mridul Kumar Saha, MD (Pathology), Assistant Professor, Department of Pathology. Manikganj Medical College, Manikganj. ORCID: https://orcid.org/0009-0007-2079-7757.   
  5. Dr. SM Nazmul Alam, MD (Pathology), Assistant Professor, Department of Pathology, Tangail medical College hospital, Tangail. ORCID: https://orcid.org/0009-0007-8847-7514.
  6. Dr. Farjana Pervin Nupur, MD (Pathology), Assistant Professor, Department of Pathology, Dhaka Medical College, Dhaka. ORCID: https://orcid.org/0009-0009-5416-1073.
  7. Dr. Pamia Arika Jahan, MBBS, Shaheed Monsur Ali Medical College, Dhaka ORCID: https://orcid.org/0009-0006-9103-4864.

*For correspondence

Abstract

Background: The liver is affected by a wide range of non-neoplastic and neoplastic lesions, requiring accurate diagnosis for appropriate management and prognostication. Image-guided cytology and biopsy are important diagnostic tools for evaluation of hepatic lesions.
Objective: To assess the spectrum of hepatic lesions diagnosed by ultrasonography-guided fine needle aspiration cytology (FNAC) and core biopsy, and to analyze their demographic and pathological distribution.
Methods: This retrospective descriptive cross-sectional study was conducted in a private laboratory in Tangail, Bangladesh, from March 2025 to March 2026. A total of 37 cases of radiologically detected hepatic lesions were included by consecutive sampling. Among them, 30 cases underwent USG-guided FNAC and 7 cases underwent USG-guided core needle biopsy. Clinical, radiological, cytological, and histopathological data were reviewed. Data were entered and analyzed using SPSS version 26.0. Continuous variables were expressed as mean ± standard deviation, while categorical variables were presented as frequency and percentage.
Results: The mean age of the patients was 54.95 ± 13.39 years, with most cases in the 41–60 years age group (54.1%). Male patients predominated (64.9%). Metastatic carcinoma was the most common lesion (62.2%), followed by non-neoplastic lesions (18.9%), hepatocellular carcinoma (13.5%), benign lesions (5.4%), and cholangiocarcinoma (2.7%). Metastatic adenocarcinoma was the most frequent malignant subtype. Radiological-pathological concordance was 83.8%.
Conclusion: Metastatic tumors were the predominant hepatic lesions, while hepatocellular carcinoma was the most common primary malignancy. Combined use of radiology, FNAC, and core biopsy remains valuable for accurate diagnosis and management of hepatic lesions.
[Journal of Histopathology and Cytopathology, 2026 Jul; 10 (2):104-110]
DOI: https://www.doi.org/10.69950/jhc.2026.10.2.4
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