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jhc2026v10i2s4


Original
Spectrum of Hepatic Lesions Diagnosed by Image-Guided Cytology and Core Needle Biopsy: A Retrospective Clinicopathological Study
*Quruni MO,1 Hossain MS,2 Afrin SS,3 Saha MK,4 Alam SN,5 Nupur FP,6 Jahan PA7
 

  1. *Dr. Md Oyes Quruni, MD (Pathology), Assistant Professor and Head, Department of Pathology, Tangail Medical College, Tangail. oyesquruni@gmail.com. ORCID: https://orcid.org/0009-0004-9184-3173.
  2. Dr. Md. Shahadat Hossain, MD (Pathology), Lecturer, Department of Pathology, Dhaka Medical College, Dhaka. ORCID: https://orcid.org/0009-0003-4384-4684.
  3. Dr. Syeda Sadia Afrin, MD (Pathology) Assistant Professor, Department of Pathology, Dhaka Medical College, Dhaka. ORCID: https://orcid.org/0009-0005-7257-3583.
  4. Dr. Mridul Kumar Saha, MD (Pathology), Assistant Professor, Department of Pathology. Manikganj Medical College, Manikganj. ORCID: https://orcid.org/0009-0007-2079-7757.   
  5. Dr. SM Nazmul Alam, MD (Pathology), Assistant Professor, Department of Pathology, Tangail medical College hospital, Tangail. ORCID: https://orcid.org/0009-0007-8847-7514.
  6. Dr. Farjana Pervin Nupur, MD (Pathology), Assistant Professor, Department of Pathology, Dhaka Medical College, Dhaka. ORCID: https://orcid.org/0009-0009-5416-1073.
  7. Dr. Pamia Arika Jahan, MBBS, Shaheed Monsur Ali Medical College, Dhaka ORCID: https://orcid.org/0009-0006-9103-4864.

*For correspondence

Abstract

Background: The liver is affected by a wide range of non-neoplastic and neoplastic lesions, requiring accurate diagnosis for appropriate management and prognostication. Image-guided cytology and biopsy are important diagnostic tools for evaluation of hepatic lesions.
Objective: To assess the spectrum of hepatic lesions diagnosed by ultrasonography-guided fine needle aspiration cytology (FNAC) and core biopsy, and to analyze their demographic and pathological distribution.
Methods: This retrospective descriptive cross-sectional study was conducted in a private laboratory in Tangail, Bangladesh, from March 2025 to March 2026. A total of 37 cases of radiologically detected hepatic lesions were included by consecutive sampling. Among them, 30 cases underwent USG-guided FNAC and 7 cases underwent USG-guided core needle biopsy. Clinical, radiological, cytological, and histopathological data were reviewed. Data were entered and analyzed using SPSS version 26.0. Continuous variables were expressed as mean ± standard deviation, while categorical variables were presented as frequency and percentage.
Results: The mean age of the patients was 54.95 ± 13.39 years, with most cases in the 41–60 years age group (54.1%). Male patients predominated (64.9%). Metastatic carcinoma was the most common lesion (62.2%), followed by non-neoplastic lesions (18.9%), hepatocellular carcinoma (13.5%), benign lesions (5.4%), and cholangiocarcinoma (2.7%). Metastatic adenocarcinoma was the most frequent malignant subtype. Radiological-pathological concordance was 83.8%.
Conclusion: Metastatic tumors were the predominant hepatic lesions, while hepatocellular carcinoma was the most common primary malignancy. Combined use of radiology, FNAC, and core biopsy remains valuable for accurate diagnosis and management of hepatic lesions.
[Journal of Histopathology and Cytopathology, 2026 Jul; 10 (2):104-110]
DOI: https://www.doi.org/10.69950/jhc.2026.10.2.4
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