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jhc2026v10i2s5


Original
Immunohistochemical Expression of Extracellular Matrix Metalloproteinase Inducer (EMMPRIN/CD147) in Renal Cell Carcinoma and Its Association with Histological Grade and Pathological Stage
*Mahmud S,¹ Bhuiyan AZ,2  Hossain SA,3 Yasmin R,4  Saha MK,5 Masud MR,6 Shakila J,7  Afrin S8

  1. *Dr. SMA Mahmud, MD (Pathology), Assistant Professor, Department of Pathology, National Institute of Laboratory Medicine and Referral Center, Dhaka. mahmudmoon@gmail.com. ORCID:https://orcid.org/ 0009-0001-8975-2406
  2. Dr. ARM Zakaria Bhuiyan, MD (Pathology), Lecturer, Department of Pathology, Mymensingh Medical College, Mymensingh. ORCID:https://orcid.org/0009-0007-9374-6854.
  3. Dr. Shaikh Alamgir Hossain, MD (Pathology), Professor, Ex-Head Department of Pathology, Mymensingh Medical College, Mymensingh.
  4. Dr. Rubina Yasmin, MD (Pathology), Associate Professor, Department of Pathology, Mymensingh Medical College, Mymensingh. ORCID:https://orcid.org/0009-0005-4011-7056.
  5. Dr. Mridul Kumar Saha, MD (Pathology), Assistant Professor, Department of Pathology, Manikganj Medical College, Manikganj. ORCID:https://orcid.org/0009-0007-2079-7757.
  6. Dr. Md. Rakibul Islam Masud, FCPS (Radiotherapy), Radiotherapist, Department of Radiotherapy, MMCH, Mymensingh. ORCID:https://orcid.org/0009-0005-9509-1375.
  7. Dr. Jobaida Shakila, MBBS, Ex Assistant Registrar, Department of Gynaecology and Obstetrics, Delta Hospital Limited, Dhaka. ORCID:https://orcid.org/0009-0008-0778-
  8. Dr. Sadia Afrin, MBBS, Army Medical College, Jashore . ORCID:https://orcid.org/0009-0002-5326-3413. 

*For correspondence
Abstract
Background: Renal cell carcinoma (RCC) is the commonest malignant epithelial tumor of kidney. Histological grade and stage are major prognostic indicators; however, additional biomarkers may improve prognostic assessment. EMMPRIN/CD14 is associated with tumor invasion, angiogenesis, and metastasis. The aim of this study is to evaluate immunohistochemical expression of EMMPRIN/CD147 in RCC and determine its association with histological grade and pathological stage.
Methods: This cross-sectional study included 40 nephrectomy specimens diagnosed as RCC. Histological grading was done according to WHO/ISUP system and staging by AJCC TNM classification. Immunohistochemical staining for EMMPRIN/CD147 was performed and scored by intensity and proportion of stained cells.
Results: Clear cell RCC was the commonest subtype (67.5%). High EMMPRIN expression was observed in 27 (67.5%) cases. Strong membranous and cytoplasmic positivity was more frequent in higher grade and advanced stage tumors. Significant association was found between EMMPRIN expression and histological grade and pathological stage (p<0.05).
Conclusion: EMMPRIN/CD147 high expression is associated with aggressive behavior of RCC and may be a useful prognostic biomarker.
[Journal of Histopathology and Cytopathology, 2026 Jul; 10 (2):111-117]
DOI: https://www.doi.org/10.69950/jhc.2026.10.2.5

 

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