Journal of Histopathology and Cytopathology

Official Journal of Bangladesh Academy of Pathology

Vol 10, No 1, January 2026

Histopathologic Findings of Breast Lesions and It’s Association with Corresponding Radiologic Findings.

*Datta T,¹ Asaduzzaman,² Ray TK,³ Hoque MM⁴

Abstract
Background: Invasive breast carcinoma is one of the most common carcinoma in women. Breast Imaging-Reporting and Data System (BI-RADS) classification besides histopathology has become an important tool for evaluation of malignant breast diseases. The purpose of this study is to assess the similarity between radiological and histopathological findings and illustrate the predictive value in the BI-RADS category.
Methods: This is a retrospective study, done at National Institute of Burn and Plastic Surgery, Dhaka from January 2023 to December 2023, included those patients who had radiological examination with BI-RADS categories 3, 4 and 5 followed by histopathological examination to confirm the diagnosis based on breast core biopsy and excision specimen within 1 year. The clinico-radiologic features were correlated with the histopathologic results using the chi- square test. The scoring system was designed based on the significant predictive features of malignancy, and its diagnostic performance was compared with that of the Breast Imaging-Reporting and Data System (BI-RADS) category.
Result: Among 111 cases, by histopathological diagnosis, malignancy was found in 54 cases (48.6%) and benign was found in 57 cases (51.4%). BI-RADS scoring category 3,4 and 5 cases were 51(45.9%), 26(23.4%) and 34(30.6%) respectively. P-value from Chi-square test shows strong association of malignancy with age ≥50, post-menopause and higher BI-RADS categories like 4 and 5. Overall, the breast lesions evaluated by BI-RADS classification have a sensitivity of 94.48%, specificity of 43.14%, a PPV of 63.9% and a NPV of 88%.
Conclusion: A strong association was found between BI-RADS score 4,5 and histopathologically diagnosed malignant lesion.

[Journal of Histopathology and Cytopathology, 2026 Jan; 10 (1):63-70]
DOI: https://www.doi.org/10.69950/jhc.2026.10.1.8

Keywords: Breast Lesion, BI-RADS, Histopathology, Association.

1. *Dr. Tanusree Datta, MBBS, MD (Pathology), Assistant Professor, Pathology Department, National Institute of Burn and Plastic Surgery, Dhaka. tanusreebsmmu89@gmail.com.
2. Dr. Asaduzzaman, MBBS, MD (Pathology), Associate Professor, Pathology Department, National Institute of Burn and Plastic Surgery, Dhaka.
3. Dr. Major Tapan Kumar Ray, MBBS, FCPS Trainee Officer, Combined Military Hospital, Dhaka.
4. Dr. Mohammad Mahabubul Hoque, MBBS, MD (Pathology), M. Med, Associate Professor, Pathology Department, National Institute of Laboratory Medicine and Referral Centre, Dhaka.

*For correspondence
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